Mechanical damage is one of the predisposing factors of inflammation, and it runs through
the entire inflammatory pathological process. Repeated or persistent damaging mechanical …

Hypertension is a global public health issue and the leading cause of premature death in
humans. Despite more than a century of research, hypertension remains difficult to cure due …

The pathophysiology of vascular disease is linked to accelerated biological aging and a
combination of genetic, lifestyle, biological, and environmental risk factors. Within the …

Over 200 million individuals worldwide are estimated to have peripheral artery disease
(PAD). Although the term peripheral can refer to any outer branch of the vasculature, the …

As the prevalence of vascular calcification (VC), a strong contributor to cardiovascular
morbidity and mortality, continues to increase, the need for pharmacologic therapies …

Medial arterial calcification (MAC), a systemic vascular disease different from
atherosclerosis, is associated with an increased incidence of cardiovascular events. Several …

Spatial multi-omic studies have emerged as a promising approach to comprehensively
analyze cells in tissues, enabling the joint analysis of multiple data modalities like …

Recent studies have shown that short-chain fatty acids (SCFAs), primarily acetate,
propionate and butyrate, play a crucial role in the pathogenesis of cardiovascular disease …

Aging of the vasculature, which is integral to the functioning of literally all human organs,
serves as a fundamental physiological basis for age-related alterations as well as a shared …

Vascular calcification (VC), an actively regulated process, has been recognized as an
independent and strong predictor of cardiovascular disease (CVD) and mortality worldwide …