Human exposure to highly nickel-polluted environments, such as those associated with
nickel refining, electroplating, and welding, has the potential to produce a variety of …

Although carcinogenic metals have been known to disrupt a wide range of cellular
processes the precise mechanism by which they exert their carcinogenic effects is not …

This review discusses the modes of coordination of oligopeptides by Cu (II) and Ni (II).
Special attention is given to two general classes of peptides. The first part of the review …

DNA methylation and histone modification promote changes in chromatin structure that may
affect gene expression in a heritable manner without directly altering the genome. As such …

The metal ions carcinogenic to humans are As, Be, Cd, Cr and Ni, and the candidates also
include Co, Cu, Fe and Pt. A range of molecular mechanisms was proposed for these …

Eukaryotic histone H3-H4 tetramers contain a putative copper (Cu2+) binding site at the H3-
H3′ dimerization interface with unknown function. The coincident emergence of eukaryotes …

Guanine-specific modification of both single-and double-stranded oligodeoxynucleotides via
the autoxidation of sulfite is shown to be catalyzed by [NiCR] 2+(where CR= 2, 12-dimethyl …

This review is focused on the general mechanisms of metal toxicity in humans. The possible
and mainly confirmed mechanisms of their action are discussed. The metals are divided into …

Nickel compounds are known human carcinogens, but the exact molecular mechanisms of
nickel carcinogenesis are not known. Due to their abundance, histones are likely targets for …

The acetyl-TESHHK-amide peptide, modeling a part of the C-terminal “tail” of histone H2A,
was found previously by us to undergo at pH 7.4 a Ni (II)-assisted hydrolysis of the E− S …