Idiopathic pulmonary fibrosis (IPF) is a fatal age-associated disease that is characterized by
progressive and irreversible scarring of the lung. The pathogenesis of IPF is not completely …

Background Inflammation in the lung is the body's natural response to injury. It acts to
remove harmful stimuli such as pathogens, irritants, and damaged cells and initiate the …

Immune responses to pathogens are complex and not well understood in many diseases,
and this is especially true for infections by persistent pathogens. One mechanism that allows …

Background Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease. Repetitive
injury and reprogramming of the lung epithelium are thought to be critical drivers of disease …

Cells in vivo reside within complex microenvironments composed of both biochemical and
biophysical cues. The dynamic feedback between cells and their microenvironments hinges …

Despite intensive research efforts, several fundamental disease processes for tuberculosis
(TB) remain poorly understood. A central enigma is that host immunity is necessary to …

Accumulating evidence suggests that fibrosis is a multicellular process with contributions
from alveolar epithelial cells (AECs), recruited monocytes/macrophages, and fibroblasts. We …

Mycobacterium tuberculosis (Mtb) infection causes tuberculosis (TB), a disease
characterized by development of granulomas. Granulomas consist of activated immune cells …

The severity of the COVID-19 pandemic has created an emerging need to investigate the
long-term effects of infection on patients. Many individuals are at risk of suffering pulmonary …

Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is a pulmonary
pathogen of major global concern. A key feature of Mtb infection in primates is the formation …