Physiologically-based pharmacokinetic simulation modelling
GM Grass, PJ Sinko - Advanced Drug Delivery Reviews, 2002 - Elsevier
Drug selection is now widely viewed as an important and relatively new, yet largely
unsolved, bottleneck in the drug discovery and development process. In order to achieve an …
unsolved, bottleneck in the drug discovery and development process. In order to achieve an …
Model-based drug development: the road to quantitative pharmacology
L Zhang, V Sinha, ST Forgue, S Callies, L Ni… - … of pharmacokinetics and …, 2006 - Springer
High development costs and low success rates in bringing new medicines to the market
demand more efficient and effective approaches. Identified by the FDA as a valuable …
demand more efficient and effective approaches. Identified by the FDA as a valuable …
[图书][B] The art of modeling
PL Bonate - 2006 - Springer
The focus of this book is primarily on the development of pharmacokinetic and
pharmacokinetic-pharmacodynamic models. Models that are reported in the literature are …
pharmacokinetic-pharmacodynamic models. Models that are reported in the literature are …
[图书][B] Modeling in biopharmaceutics, pharmacokinetics and pharmacodynamics: homogeneous and heterogeneous approaches
P Macheras, A Iliadis - 2016 - books.google.com
The state of the art in Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics
Modeling is presented in this new second edition book. It shows how advanced physical and …
Modeling is presented in this new second edition book. It shows how advanced physical and …
Trends in the development of microfluidic cell biochips for in vitro hepatotoxicity
Current developments in the technological fields of liver tissue engineering, bioengineering,
biomechanics, microfabrication and microfluidics have lead to highly complex and pertinent …
biomechanics, microfabrication and microfluidics have lead to highly complex and pertinent …
Interdisciplinary applied mathematics
SSAJE Marsden, LSS Wiggins, L Glass, RV Kohn… - 1993 - Springer
Problems in engineering, computational science, and the physical and biological sciences
are using increasingly sophisticated mathematical techniques. Thus, the bridge between the …
are using increasingly sophisticated mathematical techniques. Thus, the bridge between the …
Probabilistic models for drug dissolution. Part 1. Review of Monte Carlo and stochastic cellular automata approaches
Throughout the last decades, Monte Carlo (MC) techniques have been used in simulating
various complex systems. In this paper, we investigate how MC-based methods are used in …
various complex systems. In this paper, we investigate how MC-based methods are used in …
Modeling and simulation for clinical trial design involving a categorical response: a phase II case study with naratriptan
I Nestorov, G Graham, S Duffull, L Aarons… - Pharmaceutical …, 2001 - Springer
Purpose. The overall aim of the present study was to investigate retrospectively the
feasibility and utility of model-based clinical trial simulation as applied to the clinical …
feasibility and utility of model-based clinical trial simulation as applied to the clinical …
药代动力学和药效动力学中数学建模与模拟的基本原理(1)
黄晓晖， 史军， 李俊， 谢海棠… - … 临床药理学与治疗学, 2007 - manu41.magtech.com.cn
数学建模与模拟(modeling and simulation, M&S) 是药代动力学(药动学) 与药效动力学(药效学)
中重要的定量研究方法, 在研究药物的处置和作用的机理, 治疗药物监测及新药开发中发挥越来 …
中重要的定量研究方法, 在研究药物的处置和作用的机理, 治疗药物监测及新药开发中发挥越来 …
Use of the dose, time, susceptibility (DoTS) classification scheme for adverse drug reactions in pharmacovigilance planning
T Callréus - Drug safety, 2006 - Springer
In the process of conceiving a pharmacovigilance plan, as proposed in the International
Conference on Harmonisation E2E guideline, the challenge will be how to address possible …
Conference on Harmonisation E2E guideline, the challenge will be how to address possible …