The science of drug discovery has been witnessing paradigm shifts in the recent past. The
new directions can be attributed to several factors such as availability of genome …

This chapter will review some of the important methods for carrying out in vivo absorption
and bioavailability studies, as well as attempt to provide an overview of how the information …

Information concerning the relationship between pharmacokinetics and pharmacodynamics
is es sential for physicians and pharmacists when deciding a dosage regimen of drug …

Modeling plays a central role in the present thesis. This chapter gives an overview starting
with an introduction (Chapter 1.2. 1), followed by a brief review of modeling in drug …

Desferal®(desferrioxamine) is the most widely used iron chelator for the treatment of
transfusion-dependent iron overload in beta-thalassaemia major. Its short half-life and poor …

Modeling and simulation (M&S) is an important research field in pharmacokinetics and
pharmacodynamics. M&S has evolved from a tool primarily applied to therapeutic drug …

Information concerning the relationship between pharmacokinetics and pharmacodynamics
is essential for physicians and pharmacists when deciding a dosage regimen of drug …

This chapter contains sections titled: Sources of Variability The Standard Approach The
Population Approach Population Versus Standard Approach: An Example Pharmacokinetic …