Neurotoxicity and underlying mechanisms of endogenous neurotoxins

Y Cao, B Li, N Ismail, K Smith, T Li, R Dai… - International journal of …, 2021 - mdpi.com
Endogenous and exogenous neurotoxins are important factors leading to
neurodegenerative diseases. In the 1980s, the discovery that 1-methyl-4-phenyl-1, 2, 3, 6 …

Alcohol and breast cancer

B Starek-Świechowicz, B Budziszewska… - Pharmacological …, 2023 - Springer
Breast cancer is one of the main causes of death in women worldwide. In women, breast
cancer includes over half of all tumours caused by alcohol. This paper discusses both …

Geographical discrimination of Flos Trollii by GC-MS and UHPLC-HRMS-based untargeted metabolomics combined with chemometrics

QY Du, M He, X Gao, X Yu, JN Zhang, J Shi… - … of Pharmaceutical and …, 2023 - Elsevier
Abstract For centuries, Flos Trollii has been consumed as functional tea and a folk medicine
in China's north and northwest zones. The quality of Flos Trollii highly depends on the …

Traditional Chinese medicines treat ischemic stroke and their main bioactive constituents and mechanisms

G Fan, M Liu, J Liu, Y Huang, W Mu - Phytotherapy Research, 2024 - Wiley Online Library
Ischemic stroke (IS) remains one of the leading causes of death and disability in humans.
Unfortunately, none of the treatments effectively provide functional benefits to patients with …

Benzophenone Derivatives with Histamine H3 Receptor Affinity and Cholinesterase Inhibitory Potency as Multitarget-Directed Ligands for Possible Therapy of …

J Godyń, P Zaręba, D Stary, M Kaleta, KJ Kuder… - Molecules, 2022 - mdpi.com
The multitarget-directed ligands demonstrating affinity to histamine H3 receptor and
additional cholinesterase inhibitory potency represent a promising strategy for research into …

[HTML][HTML] Anti-inflammatory effects of banana (Musa balbisiana) peel extract on acne vulgaris: In vivo and in silico study

D Savitri, S Wahyuni, A Bukhari, K Djawad… - Journal of Taibah …, 2023 - ncbi.nlm.nih.gov
Objective Acne vulgaris (AV) is a common problem with a relatively high incidence rate
among Asian people. The potential antimicrobial and anti-inflammatory properties of banana …

Antioxidant Capacity, Antitumor Activity and Metabolomic Profile of a Beetroot Peel Flour

PPS Coimbra, ACAG Silva-e-Silva, AS Antonio… - Metabolites, 2023 - mdpi.com
In this study, a beetroot peel flour was made, and its in vitro antioxidant activity was
determined in aqueous (BPFw) and ethanolic (BPFe) extracts. The influence of BPFw on …

Carving the senescent phenotype by the chemical reactivity of catecholamines: An integrative review

AG Golubev - Ageing Research Reviews, 2022 - Elsevier
Macromolecules damaged by covalent modifications produced by chemically reactive
metabolites accumulate in the slowly renewable components of living bodies and …

Salsolinol Protects SH-SY5Y Cells Against MPP+ Damage and Increases Enteric S100-Immunoreactivity in Wistar Rats

M Kurnik-Łucka, G Latacz, J Goryl… - Neurochemical …, 2023 - Springer
Abstract A dopamine derivative, 1-methyl-6, 7-dihydroxy-1, 2, 3, 4-tetrahydroisoquinoline,
known as salsolinol (SAL), has increasingly gained attention since its first detection in the …

Dual Target Ligands with 4-tert-Butylphenoxy Scaffold as Histamine H3 Receptor Antagonists and Monoamine Oxidase B Inhibitors

D Łażewska, A Olejarz-Maciej, D Reiner… - International journal of …, 2020 - mdpi.com
Dual target ligands are a promising concept for the treatment of Parkinson's disease (PD). A
combination of monoamine oxidase B (MAO B) inhibition with histamine H3 receptor (H3R) …