Polymyxins are polycationic antimicrobial peptides that are currently the last-resort
antibiotics for the treatment of multidrug-resistant, Gram-negative bacterial infections. The …

After the era of plentiful antibiotics we are alarmed by the increasing number of antibiotic
resistant strains. The genetic flexibility and adaptability of Escherichia coli to constantly …

Objectives To evaluate correlations between antimicrobial use and the prevalence of
resistance in commensal Escherichia coli isolates from pigs, poultry and cattle, using data …

Despite increasing concerns over inappropriate use of antibiotics in medicine and food
production, population-level resistance transfer into the human gut microbiota has not been …

Highlights•Antibiotics are used extensively in the swine industry.•Pigs can be a source of
antibiotic resistant organisms that impact on human health.•Extended spectrum β-lactamase …

Colistin has been used in veterinary medicine for decades, mainly for the prevention and
treatment of Enterobacteriaceae infections. However, data regarding colistin resistance in …

Colistin is a cyclic decapeptide bound to a fatty acid chain. It is active against many Gram-
negative bacteria by destabilising the bacterial outer membrane. Bacteria can become …

Colistin, a cationic polypeptide antibiotic, has reappeared in human medicine as a last-line
treatment option for multidrug-resistant Gram-negative bacteria (MDR-GNB). Colistin is …

Colistin has been re-assessed as a critically important antimicrobial in humans due to its
efficacy against multi-drug resistant Gram-negative bacteria, in particular P. aeruginosa, A …

Multidrug resistance among pathogenic bacteria is imperilling the worth of antibiotic
infection, which has become an emerging problem, which previously transformed the …