Review The Cancer Genome Atlas (TCGA): an immeasurable source of knowledge
K Tomczak, P Czerwińska… - Contemporary Oncology …, 2015 - termedia.pl
The Cancer Genome Atlas (TCGA) is a public funded project that aims to catalogue and
discover major cancer-causing genomic alterations to create a comprehensive “atlas” of …
discover major cancer-causing genomic alterations to create a comprehensive “atlas” of …
Cancer transcriptome profiling at the juncture of clinical translation
M Cieślik, AM Chinnaiyan - Nature Reviews Genetics, 2018 - nature.com
Methodological breakthroughs over the past four decades have repeatedly revolutionized
transcriptome profiling. Using RNA sequencing (RNA-seq), it has now become possible to …
transcriptome profiling. Using RNA sequencing (RNA-seq), it has now become possible to …
[HTML][HTML] Microbiome analyses of blood and tissues suggest cancer diagnostic approach
Systematic characterization of the cancer microbiome provides a unique opportunity to
develop cancer diagnostics that exploit non-human, microbial-derived molecules in a major …
develop cancer diagnostics that exploit non-human, microbial-derived molecules in a major …
SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation
Patients with coronavirus disease 2019 (COVID-19) present a wide range of acute clinical
manifestations affecting the lungs, liver, kidneys, and gut. Angiotensin-converting enzyme 2 …
manifestations affecting the lungs, liver, kidneys, and gut. Angiotensin-converting enzyme 2 …
The landscape of viral associations in human cancers
Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, for
which whole-genome and—for a subset—whole-transcriptome sequencing data from 2,658 …
which whole-genome and—for a subset—whole-transcriptome sequencing data from 2,658 …
Molecular and genetic properties of tumors associated with local immune cytolytic activity
MS Rooney, SA Shukla, CJ Wu, G Getz, N Hacohen - Cell, 2015 - cell.com
How the genomic landscape of a tumor shapes and is shaped by anti-tumor immunity has
not been systematically explored. Using large-scale genomic data sets of solid tissue tumor …
not been systematically explored. Using large-scale genomic data sets of solid tissue tumor …
The cancer microbiome atlas: a pan-cancer comparative analysis to distinguish tissue-resident microbiota from contaminants
AB Dohlman, DA Mendoza, S Ding, M Gao… - Cell host & …, 2021 - cell.com
Studying the microbial composition of internal organs and their associations with disease
remains challenging due to the difficulty of acquiring clinical biopsies. We designed a …
remains challenging due to the difficulty of acquiring clinical biopsies. We designed a …
Long-read sequencing unveils high-resolution HPV integration and its oncogenic progression in cervical cancer
L Zhou, Q Qiu, Q Zhou, J Li, M Yu, K Li, L Xu… - Nature …, 2022 - nature.com
Integration of human papillomavirus (HPV) DNA into the human genome is considered as a
key event in cervical carcinogenesis. Here, we perform comprehensive characterization of …
key event in cervical carcinogenesis. Here, we perform comprehensive characterization of …
Cellular states are coupled to genomic and viral heterogeneity in HPV-related oropharyngeal carcinoma
Head and neck squamous cell carcinoma (HNSCC) includes a subset of cancers driven by
human papillomavirus (HPV). Here we use single-cell RNA-seq to profile both HPV-positive …
human papillomavirus (HPV). Here we use single-cell RNA-seq to profile both HPV-positive …
[HTML][HTML] Non-terminally exhausted tumor-resident memory HBV-specific T cell responses correlate with relapse-free survival in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) often develops following chronic hepatitis B virus (HBV)
infection and responds poorly to immune checkpoint blockade. Here, we examined the …
infection and responds poorly to immune checkpoint blockade. Here, we examined the …