Origin and functional heterogeneity of fibroblasts
VS LeBleu, EG Neilson - The FASEB Journal, 2020 - Wiley Online Library
The inherent plasticity and resiliency of fibroblasts make this cell type a conventional tool for
basic research. But where do they come from, are all fibroblasts the same, and how do they …
basic research. But where do they come from, are all fibroblasts the same, and how do they …
[HTML][HTML] Extracellular vesicles: emerging roles, biomarkers and therapeutic strategies in fibrotic diseases
J Zhu, S Wang, D Yang, W Xu, H Qian - Journal of Nanobiotechnology, 2023 - Springer
Extracellular vesicles (EVs), a cluster of cell-secreted lipid bilayer nanoscale particles,
universally exist in body fluids, as well as cell and tissue culture supernatants. Over the past …
universally exist in body fluids, as well as cell and tissue culture supernatants. Over the past …
[HTML][HTML] Scutellarin ameliorates pulmonary fibrosis through inhibiting NF-κB/NLRP3-mediated epithelial–mesenchymal transition and inflammation
L Peng, L Wen, QF Shi, F Gao, B Huang, J Meng… - Cell death & …, 2020 - nature.com
Idiopathic pulmonary fibrosis (IPF) is featured with inflammation and extensive lung
remodeling caused by overloaded deposition of extracellular matrix. Scutellarin is the major …
remodeling caused by overloaded deposition of extracellular matrix. Scutellarin is the major …
β‐catenin‐controlled tubular cell‐derived exosomes play a key role in fibroblast activation via the OPN‐CD44 axis
S Chen, M Zhang, J Li, J Huang, S Zhou… - Journal of …, 2022 - Wiley Online Library
Tubular injury and peripheral fibroblast activation are the hallmarks of chronic kidney
disease (CKD), suggesting intimate communication between the two types of cells …
disease (CKD), suggesting intimate communication between the two types of cells …
[HTML][HTML] Tubular cell-derived exosomal miR-150-5p contributes to renal fibrosis following unilateral ischemia-reperfusion injury by activating fibroblast in vitro and in …
X Zhou, S Zhao, W Li, Y Ruan, R Yuan… - … journal of biological …, 2021 - ncbi.nlm.nih.gov
Unilateral ischemia reperfusion injury (UIRI) with longer ischemia time is associated with an
increased risk of acute renal injury and chronic kidney disease. Exosomes can transport …
increased risk of acute renal injury and chronic kidney disease. Exosomes can transport …
[HTML][HTML] Bacteria-derived extracellular vesicles in urine as a novel biomarker for gastric cancer: integration of liquid biopsy and metagenome analysis
JY Park, CS Kang, HC Seo, JC Shin, SM Kym, YS Park… - Cancers, 2021 - mdpi.com
Simple Summary Gastric cancer shows an improved prognosis when diagnosed in its early
stage. However, non-invasive diagnostic markers for gastric cancer known to date have poor …
stage. However, non-invasive diagnostic markers for gastric cancer known to date have poor …
[HTML][HTML] Genome-wide mRNA profiling in urinary extracellular vesicles reveals stress gene signature for diabetic kidney disease
Urinary extracellular vesicles (uEV) are a largely unexplored source of kidney-derived
mRNAs with potential to serve as a liquid kidney biopsy. We assessed∼ 200 uEV mRNA …
mRNAs with potential to serve as a liquid kidney biopsy. We assessed∼ 200 uEV mRNA …
[HTML][HTML] Lipoproteins Are Responsible for the Pro-Inflammatory Property of Staphylococcus aureus Extracellular Vesicles
PK Kopparapu, M Deshmukh, Z Hu… - International Journal of …, 2021 - mdpi.com
Staphylococcal aureus (S. aureus), a Gram-positive bacteria, is known to cause various
infections. Extracellular vesicles (EVs) are a heterogeneous array of membranous structures …
infections. Extracellular vesicles (EVs) are a heterogeneous array of membranous structures …
[HTML][HTML] Extracellular vesicles as source of biomarkers in glomerulonephritis
M Bruschi, G Candiano, A Angeletti, F Lugani… - International journal of …, 2023 - mdpi.com
Kidney disease is a global health and healthcare burden. Glomerulonephritis (Gn), both
primary and secondary, is generally characterized by an inflammatory glomerular injury and …
primary and secondary, is generally characterized by an inflammatory glomerular injury and …
[HTML][HTML] Targeting premature renal aging: from molecular mechanisms of cellular senescence to senolytic trials
The biological process of renal aging is characterized by progressive structural and
functional deterioration of the kidney leading to end-stage renal disease, requiring renal …
functional deterioration of the kidney leading to end-stage renal disease, requiring renal …