Nicotine underlies tobacco addiction, influences tobacco use patterns, and is used as a
pharmacological aid to smoking cessation. The absorption, distribution and disposition …

Nicotine is of importance as the addictive chemical in tobacco, pharmacotherapy for
smoking cessation, a potential medication for several diseases, and a useful probe drug for …

Pharmacogenetics is the study of how interindividual variations in the DNA sequence of
specific genes affect drug response. This article highlights current pharmacogenetic …

In this provocative book, philosopher Nicholas Agar defends the idea that parents should be
allowed to enhance their children's characteristics. Gets away from fears of a Huxleyan …

Abstract The cytochrome P450 (P450) enzymes first attracted interest because of their
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …

Background Nicotine and a variety of other drugs and toxins are metabolized by cytochrome
P450 (CYP) 2A6. Our objective was to evaluate the use of oral nicotine with measurement of …

Much of P450 research has always been done with the view of appUcation to humans, even
when done with experimental animals and microorganisms. Research with the human …

The cytochromes P450 (CYPs) constitute a superfamily of hemoprotein enzymes that are
responsible for the biotransformation of numerous xenobiotics, including therapeutic agents …

Genetically variable CYP2A6 is the primary enzyme that inactivates nicotine to cotinine. Our
objective was to investigate allele frequencies among five ethnic groups and to investigate …

Nicotine is the primary addictive compound in tobacco smoke. In this review we summarize
nicotine dependence and the genetics of smoking in brief before focusing on cytochrome …