Organ-on-a-chip: Recent breakthroughs and future prospects
Q Wu, J Liu, X Wang, L Feng, J Wu, X Zhu… - Biomedical engineering …, 2020 - Springer
The organ-on-a-chip (OOAC) is in the list of top 10 emerging technologies and refers to a
physiological organ biomimetic system built on a microfluidic chip. Through a combination of …
physiological organ biomimetic system built on a microfluidic chip. Through a combination of …
Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning
SA Langhans - Frontiers in pharmacology, 2018 - frontiersin.org
Drug development is a lengthy and costly process that proceeds through several stages
from target identification to lead discovery and optimization, preclinical validation and …
from target identification to lead discovery and optimization, preclinical validation and …
Form follows function: nanoparticle shape and its implications for nanomedicine
This review is a comprehensive description of the past decade of research into
understanding how the geometry and size of nanoparticles affect their interaction with …
understanding how the geometry and size of nanoparticles affect their interaction with …
Interconnected microphysiological systems for quantitative biology and pharmacology studies
Microphysiological systems (MPSs) are in vitro models that capture facets of in vivo organ
function through use of specialized culture microenvironments, including 3D matrices and …
function through use of specialized culture microenvironments, including 3D matrices and …
Recent advances in lung-on-a-chip models
Highlights•Transition from conventional 2D models to 3D and advanced lung-on-a-chip
models.•Recent advances in lung-on-a-chip platforms and their implementation.•Numerous …
models.•Recent advances in lung-on-a-chip platforms and their implementation.•Numerous …
[HTML][HTML] Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing
U Marx, TB Andersson, A Bahinski, M Beilmann… - Altex, 2016 - ncbi.nlm.nih.gov
The recent advent of microphysiological systems–microfluidic biomimetic devices that aspire
to emulate the biology of human tissues, organs and circulation in vitro–is envisaged to …
to emulate the biology of human tissues, organs and circulation in vitro–is envisaged to …
[HTML][HTML] Full-thickness human skin-on-chip with enhanced epidermal morphogenesis and barrier function
Reconstruction of full-thickness skin equivalents with physiologically relevant cellular and
matrix architecture is gaining importance as an in vitro tool for basic research, and for the …
matrix architecture is gaining importance as an in vitro tool for basic research, and for the …
[HTML][HTML] In vitro approaches to assess the hazard of nanomaterials
B Drasler, P Sayre, KG Steinhäuser, A Petri-Fink… - NanoImpact, 2017 - Elsevier
The rapid development of engineered nanomaterials demands for a fast and reliable
assessment of their health hazard potential. A plethora of experimental approaches have …
assessment of their health hazard potential. A plethora of experimental approaches have …
Air–Liquid Interface In Vitro Models for Respiratory Toxicology Research: Consensus Workshop and Recommendations
In vitro air–liquid interface (ALI) cell culture models can potentially be used to assess
inhalation toxicology endpoints and are usually considered, in terms of relevancy, between …
inhalation toxicology endpoints and are usually considered, in terms of relevancy, between …
[HTML][HTML] A human brain microphysiological system derived from induced pluripotent stem cells to study neurological diseases and toxicity
Human in vitro models of brain neurophysiology are needed to investigate molecular and
cellular mechanisms associated with neurological disorders and neurotoxicity. We have …
cellular mechanisms associated with neurological disorders and neurotoxicity. We have …