There is a clear association between the excessive exposure to estrogens and the
development of cancer in hormone-sensitive tissues (breast, endometrium). It has become …

The aryl hydrocarbon receptor (AHR) has long been associated with the induction of a
battery of genes involved in the metabolism of foreign and endogenous compounds …

Exposure assessment is often considered the weakest link in risk assessment. It is important
for investigators to continue to utilize the full potential of biomarkers for chemicals whose …

Previous studies have shown that the selection of women who are at high breast cancer risk
for treatment with chemoprevention agents leads to an enhanced benefit/risk ratio. However …

Cytochrome P450 (CYP450) enzymes are the most important metabolizing enzyme family
exists among all organs. Apart from their role in the deactivation of most endogenous …

The formation of quinone methides (QMs) from either direct 2-electron oxidation of 2-or 4-
alkylphenols, isomerization of oquinones, or elimination of a good leaving group could …

Estrogens are major risk factors for the development of breast cancer; they can be
metabolized to catechols, which are further oxidized to DNA-reactive quinones and …

Steroid contraceptive hormones may promote human papilloma virus (HPV)-DNA
integration into the host genome, may bind to specific HPV-DNA sequences within …

Hormonal steroids have a widespread use in medicine and their side effects are
continuously debated. The possible genotoxic activity of steroids has been the subject of …

TCDD and other polyhalogenated aromatic hydrocarbon ligands of the aryl hydrocarbon
receptor (AHR) have been classically considered as non-genotoxic compounds because …