Efficient synthesis, liquid chromatography purification, and tandem mass spectrometric characterization of estrogen-modified DNA bases
Estrogens are metabolized to active quinones that modify DNA and may lead to various
cancers. To extend the analytical methodology for estrogen-modified purine bases, we …
cancers. To extend the analytical methodology for estrogen-modified purine bases, we …
Cell cycle kinetics and cytogenetic changes in human lymphocytes exposed to oestradiol in vitro
NJ Đelić, B Spremo-Potparević, B Marković… - Acta …, 2006 - doiserbia.nb.rs
Metabolic conversion of oestrogen phenolic groups may create conditions of oxidative stress
accompanied by damage of cellular macromolecules including DNA. The aim of this …
accompanied by damage of cellular macromolecules including DNA. The aim of this …
[PDF][PDF] Evaluation of DNA Damage in the Lymphocytes of Young, Elderly and Alzheimer's Disease Patients Treated with [beta]-Estradiol in the Comet Assay
L Zrskovic, N Djelic, V Bajics… - Journal of Medical …, 2013 - academia.edu
Background: The antioxidant activity of estrogen has a be neficial impact in Alzheimer's
disease. A variety of clinical studies have demonstrated that estrogen replacement therapy …
disease. A variety of clinical studies have demonstrated that estrogen replacement therapy …
Возможности прогнозирования индивидуального риска развития рака шейки матки у женщин репродуктивного возраста с помощью математического …
ЛА Клюкина, ЕА Соснова, АА Ищенко… - Опухоли женской …, 2024 - ojrs.abvpress.ru
Аннотация Введение. Рак шейки матки (РШМ) относится к раку визуальных
локализаций и у женщин репродуктивного возраста по-прежнему остается одним из …
локализаций и у женщин репродуктивного возраста по-прежнему остается одним из …
Structural and Stereoisomer Effects of Model Estrogen Quinone-Derived DNA Adducts: N6-(2-Hydroxyestron-6(α,β)-yl)-2'-deoxyadenosine and N2-(2 …
L Wang, BE Hingerty, R Shapiro… - Chemical research in …, 2004 - ACS Publications
An extensive conformational analysis has been carried out for two diastereoisomeric pairs of
model estrogen quinone-derived DNA adducts, N 6-(2-hydroxyestron-6 (α, β)-yl)-2 ' …
model estrogen quinone-derived DNA adducts, N 6-(2-hydroxyestron-6 (α, β)-yl)-2 ' …
Correlation of cervical cancers with long-term use of hormonal oral contraceptive pills-A retrospective observational multicentric study in suburban-based medical …
PS Mitra, M Barman, P Goswami, J Saha… - Asian Journal of …, 2023 - ajmsjournal.info
Background: Hormonal oral contraceptive pills (OCP) may increase the risk of carcinoma
cervix by changing the susceptibility of cervical cells to persistent infection with high-risk …
cervix by changing the susceptibility of cervical cells to persistent infection with high-risk …
Mechanisms of estrogen carcinogenesis: modulation by botanical natural products
JL Bolton - Chemical Carcinogenesis, 2010 - Springer
The longer women are exposed to estrogens, through early menarche and late menopause
and/or through hormone replacement therapy (HRT), the higher is the risk of developing …
and/or through hormone replacement therapy (HRT), the higher is the risk of developing …
Formation and reactions of xenobiotic quinone methides in biology
JL Bolton, JA Thompson - Quinone Methides, 2009 - Wiley Online Library
Quinone methides (QMs) are reactive metabolites of a variety of synthetic and natural
phenols containing ortho-or para-alkyl substituents, and are most likely responsible for the …
phenols containing ortho-or para-alkyl substituents, and are most likely responsible for the …
Xenobiotic metabolism and cancer susceptibility
O Pelkonen, K Vähäkangas, H Raunio - Mechanisms in Carcinogenesis …, 2003 - Springer
Cancer formation is a very complex process involving changes in numerous genes (Akhurst
and Balmain 1999; Sekido et al. 1999; Vähäkangas 2001). Any biological or mechanistic …
and Balmain 1999; Sekido et al. 1999; Vähäkangas 2001). Any biological or mechanistic …