The biology and pathobiology of glutamatergic, cholinergic, and dopaminergic signaling in the aging brain

A Gasiorowska, M Wydrych, P Drapich… - Frontiers in aging …, 2021 - frontiersin.org
The elderly population is growing worldwide, with important health and socioeconomic
implications. Clinical and experimental studies on aging have uncovered numerous …

Anxiety and depression: A top‐down, bottom‐up model of circuit function

DO LeDuke, M Borio, R Miranda… - Annals of the New York …, 2023 - Wiley Online Library
A functional interplay of bottom‐up and top‐down processing allows an individual to
appropriately respond to the dynamic environment around them. These processing …

[HTML][HTML] The impact of the COVID-19 pandemic on Parkinson's disease: hidden sorrows and emerging opportunities

RC Helmich, BR Bloem - Journal of Parkinson's disease, 2020 - ncbi.nlm.nih.gov
In the past few months, the world seems to have come to a virtual standstill. As the SARS-
CoV-2 virus continues to spread across the globe, many countries have taken drastic …

VTA-projecting cerebellar neurons mediate stress-dependent depression-like behaviors

SJ Baek, JS Park, J Kim, Y Yamamoto… - Elife, 2022 - elifesciences.org
Although cerebellar alterations have been implicated in stress symptoms, the exact
contribution of the cerebellum to stress symptoms remains to be elucidated. Here, we …

COVID-19 pandemic and psychiatric symptoms: the impact on Parkinson's disease in the elderly

D Janiri, M Petracca, L Moccia, L Tricoli… - Frontiers in …, 2020 - frontiersin.org
Background: The coronavirus disease 2019 (COVID-19) pandemic represents a condition of
increased vulnerability and frailty for elderly patients with Parkinson's disease (PD). Social …

Forced swim stressor: Trends in usage and mechanistic consideration

ML Molendijk, ER de Kloet - European Journal of Neuroscience, 2022 - Wiley Online Library
The acquired immobility response during the “forced swim test (FST)” is not a rodent model
of depression, but the test has some validity in predicting a compound's antidepressant …

Translational evidence for lithium-induced brain plasticity and neuroprotection in the treatment of neuropsychiatric disorders

S Puglisi-Allegra, S Ruggieri, F Fornai - Translational psychiatry, 2021 - nature.com
Increasing evidence indicates lithium (Li+) efficacy in neuropsychiatry, pointing to
overlapping mechanisms that occur within distinct neuronal populations. In fact, the same …

Stress and mindfulness in Parkinson's disease: clinical effects and potential underlying mechanisms

A van der Heide, MJ Meinders… - Movement …, 2021 - Wiley Online Library
Patients with Parkinson's disease (PD) are very vulnerable to the negative effects of
psychological distress: neuropsychiatric symptoms, such as anxiety and depression, are …

Mitochondrial gene signature in the prefrontal cortex for differential susceptibility to chronic stress

M Weger, D Alpern, A Cherix, S Ghosal, J Grosse… - Scientific reports, 2020 - nature.com
Mitochondrial dysfunction was highlighted as a crucial vulnerability factor for the
development of depression. However, systemic studies assessing stress-induced changes …

The dopamine system and automatization of movement sequences: a review with relevance for speech and stuttering

PA Alm - Frontiers in human neuroscience, 2021 - frontiersin.org
The last decades of research have gradually elucidated the complex functions of the
dopamine system in the vertebrate brain. The multiple roles of dopamine in motor function …