The serotonergic system is implicated in the neurobiological control of learning and memory,
both in healthy individuals and pathological disorders, although the underlying mechanisms …

An unfortunate result of the rapid rise in geriatric populations worldwide is the increasing
prevalence of age-related cognitive disorders such as Alzheimer's disease (AD). AD is a …

Cognitive deficits commonly accompany psychiatric disorders but are often
underrecognised, and difficult to treat. The 5-HT 4 receptor is a promising potential treatment …

The amygdala is a critical site for the acquisition of learned fear memory in mammals, and
the formation and long-term maintenance of fear memories are thought to be associated with …

The hippocampus has long been considered as a key structure for memory processes.
Multilevel alterations of hippocampal function have been identified as a common …

Since the last century, when scientists proposed the lock-and-key model, the discovery of
drugs has focused on the development of drugs acting on single target. However, single …

Proteolytic processing of the amyloid precursor protein (APP) by the β-and γ-secretases
releases the amyloid-β peptide (Aβ), which deposits in senile plaques and contributes to the …

Amyloid beta (Aβ) peptides derived from proteolytic cleavage of amyloid precursor protein
(APP) are thought to be a pivotal toxic species in the pathogenesis of Alzheimer's disease …

Background and purpose: A strategy to treat Alzheimer's disease (AD) is to increase the
soluble form of amyloid precursor protein (sAPPα), a promnesic protein, in the brain …

With the aging of the population, the incidence and prevalence of Alzheimer's disease will
grow, increasing the burden on individuals and society. While ameliorating symptoms, the …