The worldwide pandemic caused by the SARS-CoV-2 virus has resulted in over 84,407,000
cases, with over 1,800,000 deaths when this paper was submitted, with comorbidities such …

New Findings What is the topic of this review? This review presents the fundamental
concepts of respiratory physiology and pathophysiology, with particular reference to lung …

Background The aim of this study was to validate whether regional ventilation and perfusion
data measured by electrical impedance tomography (EIT) with saline bolus could …

Impaired tissue oxygen delivery is a major cause of organ damage and failure in critically ill
patients, which can occur even when systemic parameters, including cardiac output and …

Positive pressure ventilation (PPV) causes a radical departure from the physiology of
spontaneous breathing where a positive intrathoracic pressure is only generated transiently …

Very fast sensors that are able to track rapid changes in oxygen partial pressure (PO 2) in
the gas and liquid phases are increasingly required in scientific research–particularly in the …

Background Within-breath oscillations in arterial oxygen tension (PaO2) can be detected
using fast responding intra-arterial oxygen sensors in animal models. These PaO2 signals …

Two challenges in the management of Acute Respiratory Distress Syndrome are the
difficulty in diagnosing cyclical atelectasis, and in individualising mechanical ventilation …

Background Real-time bedside information on regional ventilation and perfusion during
mechanical ventilation (MV) may help to elucidate the physiological and pathophysiological …

Measurement allows us to quantify various parameters and variables in natural systems. In
addition, by measuring the effect by which a perturbation of one part of the system influences …