Many steps of RNA processing occur during transcription by RNA polymerases. Co-
transcriptional activities are deemed commonplace in prokaryotes, in which the lack of …

The uridine modifications pseudouridine (Ψ), dihydrouridine, and 5-methyluridine are
present in eukaryotic mRNAs. Many uridine-modifying enzymes are associated with human …

Alternative splicing significantly expands biological complexity, particularly in the vertebrate
nervous system. Increasing evidence indicates that developmental and tissue-dependent …

Splicing is a highly regulated process critical for proper pre-mRNA maturation and the
maintenance of a healthy cellular environment. Splicing events are impacted by ongoing …

The essential role of U4 snRNP in pre-messenger RNA (mRNA) splicing has been well
established. In this study, we utilized an antisense morpholino oligonucleotide (AMO) …

Disruptions in spatiotemporal gene expression can result in atypical brain function.
Specifically, autism spectrum disorder (ASD) is characterized by abnormalities in pre‐mRNA …

Splicing is an important step of gene expression regulation in eukaryotes, as there are many
mRNA precursors that can be alternatively spliced in different tissues, at different cell cycle …

We previously discovered using transcriptomics that rats undergoing withdrawal after
chronic ethanol exposure had increased expression of several genes encoding RNA …

Abstract Background & Aims The homeostasis of the cellular transcriptome depends on
transcription and splicing mechanisms. Moreover, the fidelity of gene expression, essential …

Prefoldins (PFDs) are ubiquitous co-chaperone proteins that originated in archaea during
evolution and are present in all eukaryotes, including yeast, mammals, and plants. Typically …