The alarmin IL-33 is an IL-1 family member that stimulates pleiotropic immune reactions
depending on the target tissue and microenvironmental factors. In this study, we have …

Background—The success of coronary reperfusion therapy in ST-segment–elevation
myocardial infarction (MI) is commonly limited by failure to restore microvascular perfusion …

IL-33 is a recently characterized IL-1 family member that is proposed to function as an
alarmin, or endogenous signal of cellular damage, as well as act as a pleiotropic cytokine …

One of the hallmarks of the vertebrate adaptive immune system is the prolific expansion of
individual cell clones that encounter their cognate antigen. More recently, however, there is …

Recent studies have highlighted a role for the alarmin interleukin (IL)-33 in CD4+ and CD8+
T cell activation and function, and have also revealed important distinctions. The IL-33 …

Here, we show that interleukin-1 (IL-1) enhances antigen-driven CD8 T cell responses.
When administered to recipients of OT-I T cell receptor transgenic CD8 T cells specific for an …

Allogeneic hematopoietic stem cell transplantation (alloSCT) is an important curative
therapy for high-risk hematological malignancies, but the development of severe and/or …

The expression and biological role of IL33 in colon cancer is poorly understood. In this
study, we show that IL33 is expressed by vascular endothelial cells and tumor cells in the …

The self–non-self theory has dominated immunology since the 1950s. In the 1990s,
Matzinger and her colleagues suggested a new, competing theory, called the “danger …

Inflammatory bowel diseases (IBD) affect over 5 million individuals in the industrialized
world, with an increasing incidence rate worldwide. IBD also predisposes affected …