A comprehensive review of drug penetration into pulmonary epithelial lining fluid (ELF) was
previously published in 2011. Since then, an extensive number of studies comparing plasma …

The challenging severity of some infections, especially in critically ill patients, makes the
diffusion of antimicrobial drugs within tissues one of the cornerstones of chemotherapy. The …

Although available data are still limited, real-world evidence regarding mainly ceftolozane-
tazobactam and ceftazidime-avibactam could support the administration of novel beta …

Critically ill patients admitted to intensive care unit (ICU) with severe infections, or those who
develop nosocomial infections, have poor outcomes with substantial morbidity and mortality …

Hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) are the
most common intensive care unit (ICU) infections. We aimed to evaluate the association of …

Objectives: The objective of this study was to explore the relationship between
pharmacokinetic/pharmacodynamic (PK/PD) target attainment of continuous-infusion (CI) …

Cefepime is commonly used in the intensive care unit (ICU) to treat bacterial infections. The
time during which the free cefepime concentration is above the MIC (f T> MIC) should be …

Prolonged infusion of beta-lactam antibiotics for Gram-negat... : Current Opinion in
Infectious Diseases Prolonged infusion of beta-lactam antibiotics for Gram-negative …

Pneumonia is one of the most common infections in intensive care patients, and it is often
treated with beta-lactam antibiotics. Even if therapeutic drug monitoring in blood is available …

Colistin heteroresistance has been identified in several bacterial species, including
Escherichia coli and Klebsiella pneumoniae, and may underlie antibiotic therapy failures …