Obesity causes a number of changes, including an increase in volume of distribution and
changes in hepatic metabolism and renal excretion. Several antibiotics have sufficient data …

High-dose chemotherapy has long been advocated as a means of controlling drug
resistance in infectious diseases but recent empirical studies have begun to challenge this …

Recent treatment guidelines for uncomplicated urinary tract infections (UTIs) discourage
fluoroquinolone prescription because of collateral damage to commensal microbiota, but the …

The successful treatment of bacterial infections is the product of a collaboration between
antibiotics and the host's immune defenses. Nevertheless, in the design of antibiotic …

The evolution of resistance to antibiotics is a major public health problem and an example of
rapid adaptation under natural selection by antibiotics. The dynamics of antibiotic resistance …

This article describes a portable microfluidic technology for determining the minimum
inhibitory concentration (MIC) of antibiotics against bacteria. The microfluidic platform …

Hospitals are considered an excellent compartment for the selection of resistant and multi-
drug resistant (MDR) bacteria. The overuse and misuse of antimicrobial agents are …

In this study, we report the early expansion, evolution, and characterization of a
multiresistant Klebsiella pneumoniae clone that was isolated with increasing frequency from …

In the face of increasing antimicrobial resistance and the paucity of new antimicrobial agents
it has become clear that new antimicrobial strategies are urgently needed. One of these is to …

Background and objective External evaluation is an important issue in the population
pharmacokinetic analysis of antibiotics. The purpose of this review was to summarize the …