Purpose The effects of iv push administration on the pharmacodynamic exposures of
meropenem, cefepime, and aztreonam were evaluated. Methods Pharmacokinetic and …

Bile acid homeostasis is critical to human health. Low-level exposure to antibiotics has been
suggested to potentially disrupt bile acid homeostasis by affecting gut microbiota, but …

Background Population pharmacokinetic (popPK) models for antibiotics are used to improve
dosing strategies and individualize dosing by therapeutic drug monitoring. Little is known …

Objectives: To assess the in vitro effect of select antimicrobials on the growth of N.
gonorrhoeae and its pharmacodynamic parameters. Methods: Time–kill assays were …

Objectives To calculate the clavulanic acid exposure of oral amoxicillin/clavulanic acid
dosing regimens, to investigate variability using a population pharmacokinetic model and to …

Dr. Theuretzbacher, principal and founder of the Center for Anti-Infective Agents in Vienna,
Austria, focuses on research, education, and strategy regarding anti-infective treatment and …

Antimicrobial resistance is a major public health issue. The pharmacokinetic/
pharmacodynamic (PK/PD) model is an essential tool to optimize dosage regimens and …

Abstract Background Systemic Escherichia coli infections cause early mortality of
commercial broiler chickens. Although enrofloxacin has long been used in poultry, the in …

Background Pharmacokinetic data on high-dose isoniazid for the treatment of rifampicin-
/multidrug-resistant tuberculosis (RR/MDR-TB) are limited. We aimed to describe the …

Background Prolonged infusion of beta-lactam antibiotics is broadly recognized as a
strategy to optimize antibiotic therapy by achieving a higher percentage of time that …