The lung-gut crosstalk in respiratory and inflammatory bowel disease

B Du, Y Fu, Y Han, Q Sun, J Xu, Y Yang… - Frontiers in Cellular and …, 2023 - frontiersin.org
Both lung and gut belong to the common mucosal immune system (CMIS), with huge surface
areas exposed to the external environment. They are the main defense organs against the …

The functional roles of short chain fatty acids as postbiotics in human gut: future perspectives

ML Ragavan, S Hemalatha - Food Science and Biotechnology, 2024 - Springer
The significance of gut microbiome and their metabolites (postbiotics) on human health
could be a promising approach to treat various diseases that includes inflammatory bowel …

The gut microbiome as a biomarker of differential susceptibility to SARS-CoV-2

A Sarkar, S Harty, AH Moeller, SL Klein… - Trends in Molecular …, 2021 - cell.com
Coronavirus disease 2019 (COVID-19) continues to exact a devastating global toll.
Ascertaining the factors underlying differential susceptibility and prognosis following viral …

Immunomodulatory effects of microbiota-derived short-chain fatty acids in autoimmune liver diseases

W Zhang, CR Mackay, ME Gershwin - The Journal of Immunology, 2023 - journals.aai.org
Nonpathogenic commensal microbiota and their metabolites and components are essential
to maintain a tolerogenic environment and promote beneficial health effects. The metabolic …

Necrotizing enterocolitis and the gut-lung axis

KA Willis, N Ambalavanan - Seminars in perinatology, 2021 - Elsevier
The recently recognized connection between the gut microbiota and pulmonary disease has
been termed the gut-lung axis. However, broader connections link the gut and the lungs and …

Cell-free supernatant of Streptococcus salivarius M18 impairs the pathogenic properties of Pseudomonas aeruginosa and Klebsiella pneumonia

S Tunçer, S Karaçam - Archives of microbiology, 2020 - Springer
M18 strain of Streptococcus salivarius is a bacterial replacement probiotic that has been
suggested for use in the oral cavity. Here, we have shown that S. salivarius M18 cell-free …

Microbiota-related effects of prebiotic fibres in lipopolysaccharide-induced endotoxemic mice: short chain fatty acid production and gut commensal translocation

S Fan, Z Zhang, Y Zhong, C Li, X Huang, F Geng… - Food & Function, 2021 - pubs.rsc.org
Fructans such as fructo-oligosaccharides (FOS) and inulin have been reported to directly
regulate ileal inflammatory responses in lipopolysaccharide (LPS)-induced endotoxemic …

Sodium propionate attenuates the lipopolysaccharide-induced epithelial–mesenchymal transition via the PI3K/Akt/mTOR signaling pathway

D Chen, Y Qiu, Z Gao, YX Wu, B Wan… - Journal of agricultural …, 2020 - ACS Publications
Short-chain fatty acids (SCFAs), especially propionate, originate from the fermentation of
dietary fiber in the gut and play a key role in inhibiting pulmonary inflammation. Chronic …

A mitochondrial polymorphism alters immune cell metabolism and protects mice from skin inflammation

P Schilf, A Künstner, M Olbrich, S Waschina… - International journal of …, 2021 - mdpi.com
Several genetic variants in the mitochondrial genome (mtDNA), including ancient
polymorphisms, are associated with chronic inflammatory conditions, but investigating the …

The short-chain free fatty acid receptor FFAR3 is expressed and potentiates contraction in human airway smooth muscle

K Mizuta, H Sasaki, Y Zhang… - American Journal of …, 2020 - journals.physiology.org
Emerging evidence suggests that gut microbiota-derived short-chain fatty acids (SCFAs;
acetate, propionate, and butyrate) are important modulators of the inflammatory state in …