Alzheimer's and Parkinson's disease therapies in the clinic

P Chopade, N Chopade, Z Zhao… - Bioengineering & …, 2023 - Wiley Online Library
Alzheimer's disease (AD) and Parkinson's disease (PD) are the most prevalent
neurodegenerative diseases, affecting millions and costing billions each year in the United …

To restrict or not to restrict? Practical considerations for optimizing dietary protein interactions on levodopa absorption in Parkinson's disease

C Rusch, R Flanagan, H Suh, I Subramanian - npj Parkinson's Disease, 2023 - nature.com
Administration of levodopa for Parkinson's disease (PD) has remained the most effective
therapy for symptom management despite being in use for over 50 years. Advancing …

Heat‐killed Lactobacillus murinus confers neuroprotection against dopamine neuronal loss by targeting NLRP3 inflammasome

HX Fan, S Sheng, DD Li, JJ Li… - Bioengineering & …, 2023 - Wiley Online Library
The intestinal flora has become very active in studies related to Parkinson's disease (PD) in
recent years. The microbe‐gut‐brain axis is closely related to the maintenance of brain …

The adenosine A2A receptor antagonist/inverse agonist, KW-6356 enhances the anti-parkinsonian activity of L-DOPA with a low risk of dyskinesia in MPTP-treated …

Y Ohno, E Okita, M Kawai-Uchida, Y Shoukei… - Journal of …, 2023 - Elsevier
The adenosine A 2A receptor antagonist/inverse agonist, KW-6356 has been shown to be
effective in Parkinson's disease (PD) patients as monotherapy and as an adjunct therapy to …

Endophytic Fusarium species, a unique bioresource for disaggregator of misfolded alpha-synuclein

S Vats, S Saxena - Archives of Microbiology, 2023 - Springer
Aggregation of α-synuclein into toxic oligomeric structures has been implicated in the
pathogenesis of Parkinson's disease via several key stages of fibrillation, oligomerization …

Interactions between Angiotensin Type-1 Antagonists, Statins, and ROCK Inhibitors in a Rat Model of L-DOPA-Induced Dyskinesia

A Lopez-Lopez, R Valenzuela, AI Rodriguez-Perez… - Antioxidants, 2023 - mdpi.com
Statins have been proposed for L-DOPA-induced dyskinesia (LID) treatment. Statin anti-
dyskinetic effects were related to the inhibition of the Ras-ERK pathway. However, the …

Motor and non-motor symptoms, drugs, and their mode of action in Parkinson's disease (PD): a review

N Saini, N Singh, N Kaur, S Garg, M Kaur… - Medicinal Chemistry …, 2024 - Springer
Parkinson's disease is second most common neurodegenerative disorder neurological
illness that primarily affects patients in their later years of life. Specific neurons in the brain …

Biocompatible Folic-Acid-Strengthened Ag–Ir Quantum Dot Nanozyme for Cell and Plant Root Imaging of Cysteine/Stress and Multichannel Monitoring of Hg2+ and …

Z Yan, Y Tang, Z Zhang, J Feng, J Hao, S Sun… - Analytical …, 2024 - ACS Publications
To boost the enzyme-like activity, biological compatibility, and antiaggregation effect of
noble-metal-based nanozymes, folic-acid-strengthened Ag–Ir quantum dots (FA@ Ag–Ir …

Reliable ratiometric colorimetric monitoring of dopamine in practice based on the catalytic signal amplification of nano CeO2/CuO modified carboxylated chitosan

J Hao, J Feng, S Sun, Z Cao, W Xu, L Hu, W Yao… - Chemical Engineering …, 2024 - Elsevier
To reliably monitor dopamine (DA), a common neurotransmitter, a kind of nano CeO 2/CuO
modified carboxylated chitosan nanozyme (CeO 2/CuO@ CC) was constructed under …

Effects of curcumin to counteract levodopa-induced toxicity in zebrafish

P Briñez-Gallego, DG da Costa Silva… - Journal of Toxicology …, 2023 - Taylor & Francis
Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor
dysfunction due to the death of dopaminergic neurons in the substantia nigra pars …