Immune checkpoint therapy (ICT) has dramatically altered clinical outcomes for cancer
patients and conferred durable clinical benefits, including cure in a subset of patients …

Simple Summary Merkel cell carcinoma (MCC) is a rare and highly aggressive type of skin
neuroendocrine cancer that frequently recurs and metastasizes within a relatively short …

Background Merkel cell carcinoma (MCC) is an immunogenic but aggressive skin cancer.
Even after complete resection and radiation, relapse rates are high. PD-1 and PD-L1 …

Importance Although the combination of nivolumab plus ipilimumab has unquestionable
benefit over nivolumab monotherapy in advanced melanoma, currently no summative …

Metal-free radiosensitizers, particularly iodine, have shown promise in enhancing
radiotherapy due to their suitable X-ray absorption capacities and negligible biotoxicities …

Merkel cell carcinoma is a rare, highly aggressive skin cancer with neuroendocrine
differentiation. Immune checkpoint inhibition has significantly improved treatment outcomes …

Merkel cell carcinoma (MCC) is a rare skin cancer characterized by neuroendocrine
differentiation. Its carcinogenesis is based either on the integration of the Merkel cell …

Abstract Toll-like receptors (TLRs), found on antigen-presenting cells including
macrophages and dendritic cells, are essential for identifying infections and initiating …

Immunotherapy combinations are being investigated to expand the benefit of immune
checkpoint blockade across many cancer types. Radiation combinations, in particular using …

Merkel cell carcinoma (MCC) is a rare cancer of the skin characterized by a neuroendocrine
phenotype and an aggressive clinical behavior. It frequently originates in sun-exposed body …