Diagnosis of tuberculosis, and especially the diagnosis of extrapulmonary tuberculosis, still
faces challenges in clinical practice. There are several reasons for this. Methods based on …

Background Both humoral and cell-mediated responses are associated with immunity to
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although our …

We investigated feasibility and accuracy of an interferon-γ release assay (IGRA) for
detection of T-cell responses to severe acute respiratory syndrome coronavirus 2 (SARS …

Introduction There is an increasing body of evidence surrounding the importance of a T cell-
mediated response to SARS-CoV-2 infection and after COVID-19 vaccination. In this internal …

Introduction Despite huge efforts, tuberculosis (TB) is still a major public health threat
worldwide, it is estimated that a quarter of the global population is infected by …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus
disease 2019 (COVID-19), is modifying human activity all over the world with significant …

Background Only the tuberculin skin test (TST) and two interferon-γ release assays (IGRAs),
QuantiFERON-TB Gold In-Tube and T-SPOT. TB, are currently endorsed by the World …

Purpose We compared the performance of an in-house-developed flow cytometry assay for
intracellular cytokine staining (FC-ICS) and a commercially-available cytokine release assay …

• When interpreting a tuberculosis infection diagnostic test result and considering whether
someone is at risk of developing tuberculosis disease and would likely benefit from …

The burden of tuberculosis (TB) in children and adolescents remains very significant.
Several million children and adolescents are infected with TB each year worldwide following …