Small-molecule LRRK2 inhibitors for PD therapy: Current achievements and future perspectives
J Hu, D Zhang, K Tian, C Ren, H Li, C Lin… - European Journal of …, 2023 - Elsevier
Leucine-rich repeat kinase 2 (LRRK2) is a multifunctional protein that orchestrates a diverse
array of cellular processes, including vesicle transport, autophagy, lysosome degradation …
array of cellular processes, including vesicle transport, autophagy, lysosome degradation …
Toxicity induced by ciprofloxacin and enrofloxacin: oxidative stress and metabolism
S Badawy, YQ Yang, Y Liu, MA Marawan… - Critical Reviews in …, 2021 - Taylor & Francis
Abstract Ciprofloxacin (CIP)(human use) and enrofloxacin (ENR)(veterinary use) are
synthetic anti-infectious medications that belong to the second generation of …
synthetic anti-infectious medications that belong to the second generation of …
The medicinal chemistry of caffeine
G Faudone, S Arifi, D Merk - Journal of medicinal chemistry, 2021 - ACS Publications
The purine alkaloid caffeine is the most widely consumed psychostimulant drug in the world
and has multiple beneficial pharmacological activities, for example, in neurodegenerative …
and has multiple beneficial pharmacological activities, for example, in neurodegenerative …
Insights into cytochrome P450 enzyme catalyzed defluorination of aromatic fluorides
Y Zhang, T Mokkawes… - Angewandte Chemie …, 2023 - Wiley Online Library
The biodegradability of many fluorinated compounds is limited due to the robustness of the
CF bond. Recently, experimental studies suggested the potential involvement of cytochrome …
CF bond. Recently, experimental studies suggested the potential involvement of cytochrome …
[HTML][HTML] Reciprocal interplays between MicroRNAs and pluripotency transcription factors in dictating stemness features in human cancers
The interplay between microRNAs (miRNAs) and pluripotency transcription factors (TFs)
orchestrates the acquisition of cancer stem cell (CSC) features during the course of …
orchestrates the acquisition of cancer stem cell (CSC) features during the course of …
[HTML][HTML] Lipid metabolism disorders contribute to hepatotoxicity of ICR mice induced by nitrosamines exposure
H Zhang, L Lu, C Zhao, Q Liu, Q Zhou, Y Zhang… - Environment …, 2022 - Elsevier
Health risks caused by crucial environmental carcinogens N-nitrosamines triggered
ubiquitous attention. As the liver exerted vital function through metabolic process, lipid …
ubiquitous attention. As the liver exerted vital function through metabolic process, lipid …
A Review of CYP-Mediated Drug Interactions: Mechanisms and In Vitro Drug-Drug Interaction Assessment
J Lee, JL Beers, RM Geffert, KD Jackson - Biomolecules, 2024 - mdpi.com
Drug metabolism is a major determinant of drug concentrations in the body. Drug-drug
interactions (DDIs) caused by the co-administration of multiple drugs can lead to alteration in …
interactions (DDIs) caused by the co-administration of multiple drugs can lead to alteration in …
Exploring the Mechanism of Hepatotoxicity Induced by Dictamnus dasycarpus Based on Network Pharmacology, Molecular Docking and Experimental Pharmacology
P Gao, K Chang, S Yuan, Y Wang, K Zeng, Y Jiang… - Molecules, 2023 - mdpi.com
The root bark of Dictamnus dasycarpus Turcz is a traditional Chinese medicine, Dictamni
Cortex (DC), which is mainly used in the clinical treatment of skin inflammation, eczema …
Cortex (DC), which is mainly used in the clinical treatment of skin inflammation, eczema …
Rare and common variant discovery by whole-genome sequencing of 101 Thoroughbred racehorses
T Tozaki, A Ohnuma, M Kikuchi, T Ishige, H Kakoi… - Scientific reports, 2021 - nature.com
The Thoroughbred breed was formed by crossing Oriental horse breeds and British native
horses and is currently used in horseracing worldwide. In this study, we constructed a single …
horses and is currently used in horseracing worldwide. In this study, we constructed a single …
Fluorescence-Based High-Throughput Assays for Investigating Cytochrome P450 Enzyme-Mediated Drug–Drug Interactions
R He, Z Dai, M Finel, F Zhang, D Tu, L Yang… - Drug Metabolism and …, 2023 - ASPET
The cytochrome P450 enzymes (CYPs), a group of heme-containing enzymes, catalyze
oxidative metabolism of a wide range of drugs and xenobiotics, as well as different …
oxidative metabolism of a wide range of drugs and xenobiotics, as well as different …