Leucine-rich repeat kinase 2 (LRRK2) is a multifunctional protein that orchestrates a diverse
array of cellular processes, including vesicle transport, autophagy, lysosome degradation …

Abstract Ciprofloxacin (CIP)(human use) and enrofloxacin (ENR)(veterinary use) are
synthetic anti-infectious medications that belong to the second generation of …

The purine alkaloid caffeine is the most widely consumed psychostimulant drug in the world
and has multiple beneficial pharmacological activities, for example, in neurodegenerative …

The biodegradability of many fluorinated compounds is limited due to the robustness of the
CF bond. Recently, experimental studies suggested the potential involvement of cytochrome …

The interplay between microRNAs (miRNAs) and pluripotency transcription factors (TFs)
orchestrates the acquisition of cancer stem cell (CSC) features during the course of …

Health risks caused by crucial environmental carcinogens N-nitrosamines triggered
ubiquitous attention. As the liver exerted vital function through metabolic process, lipid …

Drug metabolism is a major determinant of drug concentrations in the body. Drug-drug
interactions (DDIs) caused by the co-administration of multiple drugs can lead to alteration in …

The root bark of Dictamnus dasycarpus Turcz is a traditional Chinese medicine, Dictamni
Cortex (DC), which is mainly used in the clinical treatment of skin inflammation, eczema …

The Thoroughbred breed was formed by crossing Oriental horse breeds and British native
horses and is currently used in horseracing worldwide. In this study, we constructed a single …

The cytochrome P450 enzymes (CYPs), a group of heme-containing enzymes, catalyze
oxidative metabolism of a wide range of drugs and xenobiotics, as well as different …