BACKGROUND Chromosomal mosaicism can be detected in different stages of early life: in
cleavage stage embryos, in blastocysts and biopsied cells from blastocysts during …

Single-cell sequencing is widely used in biological and medical studies. However, its
application with multiple samples is hindered by inefficient sample processing, high …

Assisted reproductive technology (ART) refers to processing gametes in vitro and usually
involves in vitro fertilization. Originally developed for the treatment of infertility, culture of …

Abstract Preimplantation Genetic Testing (PGT) aims to reduce the chance of an affected
pregnancy or improve success in an assisted reproduction cycle. Since the first established …

Research question What is the incidence of chromosomal mosaicism in human blastocysts
and can a single trophectoderm (TE) biopsy accurately predict the chromosomal constitution …

ABSTRACT Introduction Preimplantation Genetic Testing (PGT) is a cutting-edge test used
to detect genetic abnormalities in embryos fertilized through Medically Assisted …

Pregestational genetic testing of embryos is the conventional tool in detecting genetic
disorders (fetal aneuploidy and monogenic disorders) for in vitro fertilization (IVF) …

Preimplantation genetic testing (PGT) for monogenic disorders and assisted reproductive
technology have evolved and progressed in tandem. PGT started with single-cell …

Background Genetic kidney disease is a major cause of morbidity and mortality in neonates
and end-stage renal disease (ESRD) in children and adolescents. Genetic diagnosis …

7 July 2020 marks the 30th anniversary of the first pregnancies and live births following IVF,
8 embryo biopsy and single cell genetic analysis in couples at risk of X-linked diseases …