Cytochrome P450 2D6 (CYP2D6) is a critical pharmacogene involved in the metabolism of~
20% of commonly used drugs across a broad spectrum of medical disciplines including …

The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly
polymorphic human CYP2D6 gene locus. CYP2D6 genetic variation impacts the metabolism …

Natural products continue to be major sources of bioactive compounds and drug candidates
not only because of their unique chemical structures but also because of their overall …

The goals of the Association for Molecular Pathology Clinical Practice Committee's
Pharmacogenomics (PGx) Working Group are to define the key attributes of …

The virus SARS CoV-2, which causes the respiratory infection COVID-19, continues its
spread across the world and to date has caused more than a million deaths. Although …

Extensive migration has led to the necessity of knowledge regarding the treatment of
migrants with different ethnical backgrounds. This is especially relevant for pharmacological …

Objectives To evaluate systemic lupus erythematosus (SLE) flares following
hydroxychloroquine (HCQ) reduction or discontinuation versus HCQ maintenance. Methods …

Human health is influenced by various factors; these include genetic inheritance, behavioral
lifestyle, socioeconomic and environmental conditions, and public access to care and …

The association of an individual's genetic makeup with their response to drugs is referred to
as pharmacogenomics. By understanding the relationship between genetic variants and …

Codeine is used to relieve mild to moderately severe pain, and it belongs to the drug class of
opioid analgesics. Codeine has also been prescribed to prevent coughing, though the …