Connexin channels are known to be permeable to a variety of cytoplasmic molecules. The
first observation of second messenger junctional permeability, made∼ 30 years ago …

The morphological diversity of animals, fungi, plants, and other multicellular organisms
stems from the fact that each lineage acquired multicellularity independently. A prerequisite …

Gap junctions (GJ) and hemichannels (HC) formed from the protein subunits called
connexins are transmembrane conduits for the exchange of small molecules and ions …

Pannexins are newly discovered channel proteins expressed in many different tissues and
abundantly in the vertebrate central nervous system. Based on membrane topology, folding …

Erythrocytes release ATP in response to exposure to the physiological stimulus of lowered
oxygen (O2) tension as well as pharmacological activation of the prostacyclin receptor (IPR) …

In less than a decade, a small family of channel-forming glycoproteins, named pannexins,
have captured the interest of many biologists, in large part due to their association with …

Metabolic perturbations that decrease or limit blood glucose—such as fasting or adhering to
a ketogenic diet—reduce epileptic seizures significantly. To date, the critical links between …

Pannexins (Panx) constitute a new family of gap junction type proteins. Functional
expression in paired Xenopus oocytes indicated that pannexins are capable of forming …

Abstract The P2X 7 receptor (P2X 7 R) is uniquely associated with two distinct cellular
responses: activation of a dye-permeable pathway allowing passage of molecules up to 900 …

The pannexins (Panxs) are a family of chordate proteins homologous to the invertebrate gap
junction forming proteins named innexins. Three distinct Panx paralogs (Panx1, Panx2, and …