High-grade adult-type diffuse gliomas are the most common and deadliest malignant adult
tumors of the central nervous system. Despite the advancements in the multimodality …

Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide.
As a result, pharmaceutical and non-pharmaceutical interventions modifying risk factors for …

Introduction Super-paramagnetic iron oxide nanoparticles (SPIONs) are known as promising
theranostic nano-drug carriers with magnetic resonance imaging (MRI) properties. Applying …

It has been suggested that silymarin (SIL) supplementation has positive effects on
cardiovascular health and reduces the risk of cardiometabolic syndrome (CMS). This …

Liver diseases, encompassing conditions such as cirrhosis, present a substantial global
health challenge with diverse etiologies, including viral infections, alcohol consumption, and …

Background The global prevalence of diabetes has increased sharply, with the number of
cases expected to rise from 424.9 million in 2017 to 628.6 million by 2045. Flavonoids are …

Despite their subordination in humans, to a great extent, mitochondria maintain their
independent status but tightly cooperate with the “host” on protecting the joint life quality and …

Osteoarthritis is more prevalent than any other form of arthritis and is characterized by the
progressive mechanical deterioration of joints. Glucosamine, an amino monosaccharide …

Oxidative stress is highly prevalent in maintenance hemodialysis patients and increases the
risk of cardiovascular morbidity and mortality. Silymarin (SM) is a natural compound …

Silibinin (SIL), the most active phytocompound from Silybum marianum (L.), exerts many
biological effects but has low stability and bioavailability. To overcome these drawbacks, the …