P. aeruginosa is classified as a priority one pathogen by the World Health Organisation, and
new drugs are urgently needed, due to the emergence of multidrug-resistant (MDR) strains …

Resistance threatens to render antibiotics—which are essential for modern medicine—
ineffective, thus posing a threat to human health. The discovery of novel classes of …

Colistin is regarded as a last-line drug against serious infections caused by multidrug-
resistant Gram-negative bacterial pathogens. Therefore, the emergence of mobile colistin …

Because of the rise in antibiotic resistance and the dwindling pipeline of effective antibiotics,
it is imperative to explore avenues that breathe new life into existing drugs. This is …

The emergence of antimicrobial resistance (AMR) in bacterial pathogens represents a
global health threat. The metabolic state of bacteria is associated with a range of genetic …

Plant byproducts and waste present enormous environmental challenges and an
opportunity for valorization and industrial application. Due to consumer demands for natural …

The outer membrane of Gram-negative bacteria is a formidable permeability barrier which
allows only a small subset of chemical matter to penetrate. This outer membrane barrier can …

Self-assembled polymer nanoparticles are promising antibacterials, with nonspherical
morphologies of particular interest as recent work has demonstrated enhanced antibacterial …

Introduction Superbugs are microorganisms that cause disease and have increased
resistance to the treatments typically used against infections. Recently, antibiotic resistance …

The difficulty in treating Gram-negative bacteria can largely be attributed to their highly
impermeable outer membrane (OM), which serves as a barrier to many otherwise active …