The effects of intranasal dexmedetomidine premedication in children: a systematic review
and meta-analysis Page 1 REVIEW ARTICLE/BRIEF REVIEW The effects of intranasal …

Benzodiazepines are currently among the most frequently prescribed drugs all over the
world. They act as anxiolytics, sedatives, hypnotics, amnesics, antiepileptics and muscle …

Background Prediction of the exposure of neonates, infants and children to xenobiotics is
likely to be more successful using physiologically based pharmacokinetic models than …

Physiologically based pharmacokinetic (PBPK) approaches that incorporate the
developmental physiology and ontogeny of cytochrome P450 (CYP) enzymes may have …

Aims To create a general physiologically based pharmacokinetic (PBPK) model for drug
disposition in infants and children, covering the age range from birth to adulthood, and to …

Background and objective Clearance is an important pharmacokinetic concept for scaling
dosage, understanding the risks of drug-drug interactions and environmental risk …

Linked Articles This article is commented on in the editorial by Holford NHG and Anderson
BJ. Why standards are useful for predicting doses. Br J Clin Pharmacol 2017; 83: 685–7. doi …

Introduction Oral delivery is the most common administrated drug delivery path. However,
oral administration of lipophilic drugs has some limitations: they have poor dose-response …

Premedication is important in pediatric anesthesia. This meta-analysis aimed to investigate
the role of dexmedetomidine as a premedicant for pediatric patients. A systematic literature …

Background: Premedication is considered important in pediatric anesthesia.
Benzodiazepines are the most commonly used premedication agents. Clonidine, an α2 …