Telomeres are specialized nucleoprotein structures at the ends of linear chromosomes that
prevent the activation of DNA damage response and repair pathways. Numerous factors …

Telomere biology was first studied in maize, ciliates, yeast, and mice, and in recent decades,
it has informed understanding of common disease mechanisms with broad implications for …

Telomeres are the protective end-complexes at the termini of eukaryotic chromosomes.
Telomere attrition can lead to potentially maladaptive cellular changes, block cell division …

ABSTRACT Introduction: Telomere biology disorders (TBDs) encompass a group of
illnesses caused by germline mutations in genes regulating telomere maintenance, resulting …

Telomeres, the protective ends of linear chromosomes, shorten throughout an individual's
lifetime. Telomere shortening is proposed to be a primary molecular cause of aging. Short …

Ataxia-pancytopenia (AP) syndrome is characterized by cerebellar ataxia, variable
hematologic cytopenias, and predisposition to marrow failure and myeloid leukemia …

Dyskeratosis congenita (DC) is an inherited bone marrow failure syndrome characterized
clinically by the triad of abnormal nails, reticular skin pigmentation, and oral leukoplakia, and …

The distribution of telomere length in humans is broad, but it has finite upper and lower
boundaries. Growing evidence shows that there are disease processes that are caused by …

Skin undergoes continuous renewal throughout an individual's lifetime relying on stem cell
functionality. However, a decline of the skin regenerative potential occurs with age. The …

The inherited bone marrow failure syndromes (IBMFS) typically present with significant
cytopenias in at least one haematopoietic cell lineage that may progress to pancytopenia …