Viruses are obligate intracellular parasites. Despite their dependence on host cells, viruses
are evolutionarily autonomous, with their own genomes and evolutionary trajectories locked …

The historically important phage ΦX174 kills its host bacteria by encoding a 91-residue
protein antibiotic called protein E. Using single-particle electron cryo–microscopy, we …

The circadian rhythm in humans is determined by the central clock located in the
hypothalamus's suprachiasmatic nucleus, and it synchronizes the peripheral clocks in other …

The genome streamlining theory suggests that reduction of microbial genome size optimizes
energy utilization in stressful environments. Although this hypothesis has been explored in …

Due to the fast global spreading of the Severe Acute Respiratory Syndrome Coronavirus–2
(SARS-CoV-2), prevention and treatment options are direly needed in order to control …

The discovery of nackednaviruses provided new insight into the evolutionary history of the
hepatitis B virus (HBV): The common ancestor of HBV and nackednaviruses was non …

Hepatitis B virus (HBV) infection remains a major public health threat in the Middle East and
North Africa (MENA). Phylogenetic analysis of HBV can be helpful to study the putative …

Comparative genomic analyses have provided evidence that new genetic functions can
emerge out of random nucleotide sequences. Here, we apply a direct experimental …

Virus genomes may encode overlapping or nested open reading frames that increase their
coding capacity. It is not known whether the constraints on spatial structures of the two …

Here, we exploit a deep serological profiling strategy coupled with an integrated,
computational framework for the analysis of SARS-CoV-2 humoral immune responses …