Context: The underlying molecular alterations causing sporadic parathyroid adenomas that
drive primary hyperparathyroidism have not been thoroughly defined. Objective: The aim of …

Pancreatic endocrine tumors (PETs) may be part of hereditary multiple endocrine neoplasia
type 1 (MEN1) syndrome. While MEN1 gene mutation is the only ascertained genetic …

Menin is the product of the tumor suppressor gene Men1 that is mutated in the inherited
tumor syndrome multiple endocrine neoplasia type 1 (MEN1). Menin has been shown to …

Neuroendocrine tumours (NETs) originate in tissues that contain cells derived from the
embryonic neural crest, neuroectoderm and endoderm. Thus, NETs occur at many sites in …

摘要胰高血糖素样肽‐1 (Glucagon‐like peptide‐1, GLP‐1) 是小肠在进食后分泌的主要的肠促
胰岛素激素, 其主要生物学功能是促进胰岛β 细胞分泌胰岛素. GLP‐1 通过与G‐蛋白偶联受体(G …

Menin is an essential co-factor of oncogenic MLL fusion proteins and the menin–MLL
interaction is critical for development of acute leukemia in vivo. Targeting the menin–MLL …

The identification of the multiple endocrine neoplasia type 1 (MEN1) gene in 1997 has
shown that germline heterozygous mutations in the MEN1 gene located on chromosome …

Menin, a gene product of multiple endocrine neoplasia type I (MEN1), is known to act as a
tumor suppressor to repress JunD transcription factor. However, the mechanism by which …

Multiple endocrine neoplasia type I (MEN1) is an inherited tumor syndrome characterized by
tumors in multiple endocrine organs including the parathyroids, pancreatic islets, and the …

Despite its identification in 1997, the functions of the MEN1 gene—the main gene underlying
multiple endocrine neoplasia type 1 syndrome—are not yet fully understood. In addition …