Patients suffering from multiple endocrine neoplasia type 1 (MEN1) are predisposed to
multiple endocrine tumors. The MEN1 gene product, menin, is expressed in many …

Abetted by widespread usage of acid-suppressing proton pump inhibitors (PPIs), the
mitogenic actions of the peptide hormone gastrin are being revisited as a recurring theme in …

The function of the predisposition gene to multiple endocrine neoplasia type 1 (MEN1)
syndrome remains largely unknown. Previous studies demonstrated that null mutation of the …

Abstract Multiple Endocrine Neoplasia type 1 (MEN1) is an autosomal dominant disease
characterized by endocrine tumors of the parathyroids, the pancreatic islets, and the anterior …

Multiple endocrine neoplasia type 1 (MEN1) is characterized by the combined occurrence of
tumors of the parathyroids, pancreatic islets, and anterior pituitary. In addition, some patients …

Hypothesis Multiple endocrine neoplasia type 1 (MEN 1) syndrome is an autosomal
dominant disorder caused by germline mutations in theMEN1gene and characterized by …

Menin, which is encoded by the multiple endocrine neoplasia type 1 (MEN1) gene, is a
tumor suppressor and transcriptional regulator. Menin controls proliferation and apoptosis of …

Menin, the product of the multiple endocrine neoplasia type 1 (MEN1) gene, is required for
commitment of multipotential mesenchymal stem cells to the osteoblast lineage, however, it …

Recent studies have clearly linked nuclear factor-kappaB (NF-κB), a transcription factor that
plays a central role in regulating immune and inflammatory responses, to tumor …

Mutations of the MEN1 gene, encoding the tumor suppressor menin, predispose individuals
to the cancer syndrome multiple endocrine neoplasia type 1, characterized by the …