Introduction: Intravenous tissue-plasminogen activator (tPA) remains the only approved
systemic reperfusion therapy suitable for most patients presenting timely with acute ischemic …

The ischemic penumbra is defined as the severely hypoperfused, functionally impaired, at-
risk but not yet infarcted tissue that will be progressively recruited into the infarct core. Early …

Background Prehospital stroke triage is challenged by endovascular treatment for large
vessel occlusion (LVO) being available only in major stroke centers. Conjugate eye …

Background While mechanical thrombectomy (MT) has become the standard of care for
patients with acute ischemic stroke (AIS) with emergent large-vessel occlusions (ELVO) …

Stroke is the third leading cause of years lost due to disability and the second-largest cause
of mortality worldwide. Most occurrences of stroke are brought on by the sudden occlusion of …

APC (activated protein C), derived from the plasma protease zymogen, is antithrombotic and
anti-inflammatory. In preclinical injury models, recombinant APC provides neuroprotection …

Background During the COVID-19 pandemic emergency departments have noted a
significant decrease in stroke patients. We performed a timely analysis of the Bavarian …

Perioperative stroke is an ischemic or hemorrhagic cerebral event during or up to 30 days
after surgery. It is a feared condition due to a relatively high incidence, difficulties in timely …

Objectives To establish dose reference levels (RLs) for stroke interventions while carefully
analysing the impact of clinical and technical parameters on patient exposure. Methods The …

Stroke-induced blood–brain barrier breakdown promotes complications like cerebral edema
and hemorrhagic transformation, especially in association with therapeutical recanalization …