Simple Summary Scientists use animal models to study the mechanisms of human diseases
and find new drugs to treat them. Chronic Unpredictable Mild Stress is the best animal …

Behavioral testing constitutes the primary method to measure the emotional states of
nonhuman animals in preclinical research. Emerging as the characteristic tool of the …

Experiencing chronic stress significantly increases the risk for depression. Depression is a
complex disorder with varied symptoms across patients. However, feeling of sadness and …

Rationale Low-voltage-activated or T-type Ca 2+ channels play a key role in the generation
of seizures in absence epilepsy. We have described a homozygous, gain of function …

Background Exposing rats to repeated unpredictable stressors is a popular method for
modelling depression. The sucrose preference test is used to assess the validity of this …

Subarachnoid hemorrhage (SAH) is a severe form of stroke that can cause unpredictable
and diffuse cerebral damage, which is difficult to detect until it becomes irreversible …

Major depressive disorder is a common psychiatric disorder, with∼ 30% of patients suffering
from treatment-resistant depression. Based on preclinical studies on ketamine, α-amino-3 …

Laboratory rats have excellent learning abilities and are often used in cognitive
neuroscience research. The majority of rat studies are conducted on males, whereas …

Depression affects 20% of the general population and is a leading cause of disability
worldwide, with a strong female prevalence. Current pharmacotherapies have significant …

Despite an accumulating number of studies, treatments for depression are currently
insufficient. Therefore, the search for new substances with antidepressant potential is very …