Abstract G-quadruplex (G4) DNA is a type of quadruple helix structure formed by a
continuous guanine-rich DNA sequence. Emerging evidence in recent years authenticated …

Nucleic acid sequences able to adopt a G-quadruplex conformation are overrepresented
within the human genome. This evidence strongly suggests that these genomic regions …

Sorafenib (Sor) is a multitarget kinase inhibitor used clinically to treat hepatocellular
carcinoma and renal cancer. In this study, the interaction mechanism of Sor with c-MYC G …

Developing c-MYC transcription inhibitors that target the G-quadruplex has generated
significant interest; however, few compounds have demonstrated specificity for c-MYC G …

The MYC family of oncogenes (MYC, MYCN, and MYCL) encodes a basic helix–loop–helix
leucine zipper (bHLHLZ) transcriptional regulator that is responsible for moving the cell …

Apurinic/apyrimidinic endonuclease 1/redox effector-1 (Ape1/Ref-1) is the major
apurinic/apyrimidinic (AP) endonuclease in mammalian cells. It functions mainly in the base …

Ligand-Induced duplex-quadruplex transition within the c-MYC promoter region is one of the
most studied and advanced ideas for c-MYC regulation. Despite its importance, there is a …

Morusin is a natural product that has been isolated from the bark of Morus alba, a species of
mulberry tree. It belongs to the flavonoid family of chemicals, which is abundantly present in …

G-quadruplex (G4) oligonucleotides are higher-order DNA and RNA secondary structures of
enormous relevance due to their implication in several biological processes and …

Fluorine is a necessary element for human, which is closely related to life activities, such as
metabolism of teeth and bone tissue. A small amount of fluoride ions can promote the …