[HTML][HTML] Natural products in non-alcoholic fatty liver disease (NAFLD): Novel lead discovery for drug development

L Wang, Y Yan, L Wu, J Peng - Pharmacological Research, 2023 - Elsevier
With changing lifestyles, non-alcoholic fatty liver disease (NAFLD) has become the most
prevalent liver disease worldwide. A substantial increase in the incidence, mortality, and …

Multifaceted effects of obesity on cancer immunotherapies: bridging preclinical models and clinical data

LV Vick, RJ Canter, AM Monjazeb… - Seminars in cancer biology, 2023 - Elsevier
Obesity, defined by excessive body fat, is a highly complex condition affecting numerous
physiological processes, such as metabolism, proliferation, and cellular homeostasis. These …

Prebiotics progress shifts in the intestinal microbiome that benefits patients with type 2 diabetes mellitus

L Vitetta, NN Gorgani, G Vitetta, JD Henson - Biomolecules, 2023 - mdpi.com
Hypoglycemic medications that could be co-administered with prebiotics and functional
foods can potentially reduce the burden of metabolic diseases such as Type 2 Diabetes …

TFAM-mediated intercellular lipid droplet transfer promotes cadmium-induced mice nonalcoholic fatty liver disease

J Sun, L Yan, Y Chen, T Wang, W Ali, Y Ma… - Journal of Hazardous …, 2024 - Elsevier
Abstracts Cadmium (Cd) is an important environmental pollutant. Herein, we discovered a
new way of lipid accumulation, where lipid droplets can be transferred across cells. In this …

The combined effects of high-intensity interval exercise training and dietary supplementation on reduction of body fat in adults with overweight and obesity: a …

E Gaweł, B Hall, S Siatkowski, A Grabowska… - Nutrients, 2024 - mdpi.com
Excessive body fat is associated with various comorbidities including cardiovascular
disease, type 2 diabetes mellitus and certain types of cancer. The search for effective …

Ion channels regulate energy homeostasis and the progression of metabolic disorders: Novel mechanisms and pharmacology of their modulators

W Wu, J Zheng, R Wang, Y Wang - Biochemical Pharmacology, 2023 - Elsevier
The progression of metabolic diseases, featured by dysregulated metabolic signaling
pathways, is orchestrated by numerous signaling networks. Among the regulators, ion …

Normal-weight central obesity: implications for diabetes mellitus

X Jin, J Liu, Q Cao, J Lin, G Wu, L Liu, S Jiang… - Frontiers in …, 2023 - frontiersin.org
Background Current guidelines for obesity prevention and control focus on body mass index
(BMI) and rarely address central obesity. Few studies have been conducted on the …

The causal relationship between human blood metabolites and the risk of visceral obesity: a mendelian randomization analysis

Z Wang, Q Yang - Lipids in Health and Disease, 2024 - Springer
Background We aimed to explore the causal relationship between blood metabolites and
the risk of visceral obesity, as measured by visceral adipose tissue (VAT). Methods …

The Role of Perivascular Adipose Tissue in the Pathogenesis of Endothelial Dysfunction in Cardiovascular Diseases and Type 2 Diabetes Mellitus

A Valentini, C Cardillo, D Della Morte, M Tesauro - Biomedicines, 2023 - mdpi.com
Cardiovascular diseases (CVDs) and type 2 diabetes mellitus (T2DM) are two of the four
major chronic non-communicable diseases (NCDs) representing the leading cause of death …

Inhibition of Hyperglycemia and Hyperlipidemia by Blocking Toll-like Receptor 4: Comparison of Wild-Type and Toll-like Receptor 4 Gene Knockout Mice on Obesity …

X Zhao, J Zheng, J Wang, B Li, W Huang - Biology, 2024 - mdpi.com
Simple Summary Toll-like receptor 4 (TLR4) is a transmembrane protein with important
immune activity. However, emerging evidence has shown that TLR4 also regulates glucose …