[HTML][HTML] Role of dipeptidyl peptidase-4 (DPP4) on COVID-19 physiopathology

A Sebastián-Martín, BG Sánchez, JM Mora-Rodríguez… - Biomedicines, 2022 - mdpi.com
DPP4/CD26 is a single-pass transmembrane protein with multiple functions on glycemic
control, cell migration and proliferation, and the immune system, among others. It has …

Management of type 2 diabetes in patients with compensated liver cirrhosis: Short of evidence, plenty of potential

K Arvanitakis, T Koufakis, G Kalopitas… - Diabetes & Metabolic …, 2023 - Elsevier
Background and aims Treatment of type 2 diabetes (T2D) in patients with compensated
cirrhosis is challenging due to hypoglycemic risk, altered pharmacokinetics, and the lack of …

RUNX1 promotes liver fibrosis progression through regulating TGF‐β signalling

Z Guo, X Liu, S Zhao, F Sun, W Ren… - International Journal of …, 2023 - Wiley Online Library
Liver fibrosis is caused by chronic liver injury. There are limited treatments for it, and the
pathogenesis is unclear. Therefore, there is an urgent need to explore the pathogenesis of …

How far are we from an approved drug for nonalcoholic steatohepatitis?

N Méndez-Sánchez, SC Pal… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Metabolic-associated fatty liver disease (MAFLD) previously known but still
debatable, as nonalcoholic fatty liver disease (NAFLD) is one of the main causes of chronic …

Therapeutic potential and mechanism of Chinese herbal medicines in treating fibrotic liver disease

LI Yanwei, LU Yunrui, N Mozuo, Q Sheng… - Chinese Journal of …, 2023 - Elsevier
Liver fibrosis is a pathological condition characterized by replacement of normal liver tissue
with scar tissue, and also the leading cause of liver-related death worldwide. During the …

[HTML][HTML] Changes in lipid metabolism enzymes in rat epididymal fat after chronic central leptin infusion are related to alterations in inflammation and insulin signaling

ME Casado, S Canelles, E Arilla-Ferreiro… - International Journal of …, 2023 - mdpi.com
Leptin inhibits food intake and reduces the size of body fat depots, changing adipocyte
sensitivity to insulin to restrain lipid accrual. This adipokine may modulate the production of …

Protective effects of Huang-Qi-Ge-Gen decoction against diabetic liver injury through regulating PI3K/AKT/Nrf2 pathway and metabolic profiling

ZT Zhang, QF Liang, X Wang, RS Wang… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Huang-Qi-Ge-Gen decoction (HGD) is a
traditional Chinese medicine prescription that has been used for centuries to treat …

Sangyod Rice Extract Mitigates Insulin Resistance in HepG2 cells and Hepatic Steatosis in Diabetic Rats via AMPK/mTOR/MAPK Signaling Pathways

W Hanchang, W Woonnoi, J Saetan, W Suttithumsatid… - Food Bioscience, 2024 - Elsevier
Non-alcoholic fatty liver disease (NAFLD), marked by inflammation, oxidative stress, and
insulin resistance (IR), often has a significant impact on public health. To date, Sangyod rice …

Vildagliptin ameliorates intrapulmonary vasodilatation and angiogenesis in chronic common bile duct ligation-induced hepatopulmonary syndrome in rat

SA Mangoura, MA Ahmed, N Hamad, AZ Zaka… - Clinics and Research in …, 2024 - Elsevier
Introduction Experimental hepatopulmonary syndrome (HPS) is best reproduced in the rat
common bile duct ligation (CBDL) model. Vildagliptin (Vild) is an anti-hyperglycemic drug …

Pathophysiological Features of Rat Models of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis

Y Saigo, K Uno, T Ishigure, T Odake, T Ohta - in vivo, 2024 - iv.iiarjournals.org
Nonalcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH) is caused by
various factors, including genetic and/or environmental factors, and has complicated …