Continued excessive alcohol consumption can lead to the development of dependence that
is associated with a withdrawal syndrome when alcohol consumption is ceased or …

The development of animal models that demonstrate excessive levels of alcohol
consumption has played an important role in advancing our knowledge about …

Background: The development of dependence may have significant motivational
consequences regarding continued use and abuse of ethanol. We have developed a mouse …

The central CB 1 cannabinoid receptor has recently been implicated in brain reward
function. In the present study we evaluated first the effects of the selective CB 1 receptor …

The opiate antagonist naltrexone suppresses ethanol-reinforced behavior in animals and
decreases ethanol intake in humans. However, the mechanisms underlying these actions …

Rationale We previously demonstrated that chronic ethanol exposure and withdrawal
experience significantly increased subsequent voluntary ethanol intake in C57BL/6J mice …

One of the functions of the mesolimbic dopamine (DA) system is to regulate the process of
reinforcement, a process that is thought to influence drug self‐administration. This study …

Aims: Ghrelin is a peptide hormone that antagonizes the action of leptin and is thereby
thought to regulate feeding behaviour. The actions of ghrelin and leptin appear to be …

There is increasing evidence that individual protein kinase C (PKC) isozymes mediate
specific effects of ethanol on the nervous system. In addition, multiple lines of evidence …

Mesocorticolimbic dopamine (DA) transmission has been implicated in the consummatory
and, more recently, the incentive-motivational aspect of ethanol's actions. The purpose of …