Introduction: Allostatic load refers to the cumulative burden of chronic stress and life events.
It involves the interaction of different physiological systems at varying degrees of activity …

Epidemiological evidence indicates that regular physical activity and/or frequent structured
exercise reduces the incidence of many chronic diseases in older age, including …

The aging immune system (immunosenescence) has been implicated with increased
morbidity and mortality in the elderly. Of note, T cell aging and low-grade inflammation …

Background The immunosenescence is a relatively recent chapter, correlated with the linear
extension of the average life began in the nineteenth century and still in progress. The most …

Some people remain healthier throughout life than others but the underlying reasons are
poorly understood. Here we hypothesize this advantage is attributable in part to optimal …

Aging leads to numerous changes that affect all physiological systems of the body including
the immune system, causing greater susceptibility to infectious disease and contributing to …

As is apparent from the many contributions to this Special Issue of the Journal, the impact of
age on immunity is nefarious, with all manner of dysregulated responses attributed to …

A low CD4/CD8 ratio in elderly HIV-uninfected adults is associated with increased morbidity
and mortality. A subset of HIV-infected adults receiving effective antiretroviral therapy (ART) …

Among the various mechanisms involved in aging, it was proposed long ago that a
prominent role is played by oxidative stress. A major way by which the latter can provoke …

The aging process is driven by a finite number of inter‐related mechanisms that ultimately
lead to the emergence of characteristic phenotypes, including increased susceptibility to …