Deubiquitinases (DUBs) are specialized proteases that remove ubiquitin from substrates or
cleave within ubiquitin chains to regulate ubiquitylation and therefore play important roles in …

Vitamin B6 is a fascinating molecule involved in the vast majority of changes in the human
body because it is a coenzyme involved in over 150 biochemical reactions. It is active in the …

Cancer cells reprogramme their metabolism to support unrestrained proliferation and
survival in nutrient-poor conditions. Whereas non-transformed cells often have lower …

A survey of protein databases indicates that the majority of enzymes exist in oligomeric
forms, with about half of those found in the UniProt database being homodimeric …

Defences to pathogens such as SarCoV2 in mammals involves interactions between
immune functions and metabolic pathways to eradicate infection while preventing …

The recent pandemic SARS-CoV-2 outbreak affects all kind of individuals worldwide. The
health, social and economic impact of the pandemic is dramatic and vaccines or specific …

Increasing evidence implicates metabolic pathways as key regulators of cell fate and
function. Although the metabolism of glucose, amino acids, and fatty acids is essential to …

The 21st century is witnessing an explosive surge in our understanding of pseudoenzyme-
driven regulatory mechanisms in biology. Pseudoenzymes are proteins that have sequence …

Abstract One-carbon (1C) metabolism encompasses folate-mediated 1C transfer reactions
and related processes, including nucleotide and amino acid biosynthesis, antioxidant …

Abstract Introduction: Serine hydroxymethyltransferase 2 (SHMT2) plays a critical role in
serine-glycine metabolism to drive cancer cell proliferation. However, the nonmetabolic …