Clinical delivery of circular RNA: lessons learned from RNA drug development
Circular RNAs (circRNA) represent a distinct class of covalently closed-loop RNA molecules,
which play diverse roles in regulating biological processes and disease states. The …
which play diverse roles in regulating biological processes and disease states. The …
Exosomes: A potential tool for immunotherapy of ovarian cancer
X Gong, H Chi, DF Strohmer, AT Teichmann… - Frontiers in …, 2023 - frontiersin.org
Ovarian cancer is a malignant tumor of the female reproductive system, with a very poor
prognosis and high mortality rates. Chemotherapy and radiotherapy are the most common …
prognosis and high mortality rates. Chemotherapy and radiotherapy are the most common …
Advances in mRNA therapeutics for cancer immunotherapy: from modification to delivery
RNA vaccines have demonstrated their ability to solve the issues posed by the COVID-19
pandemic. This success has led to the renaissance of research into mRNA and their …
pandemic. This success has led to the renaissance of research into mRNA and their …
P65 mediated UBR4 in exosomes derived from menstrual blood stromal cells to reduce endometrial fibrosis by regulating YAP Ubiquitination
J Qi, X Zhang, S Zhang, S Wu, Y Lu, S Li, P Li… - Journal of …, 2023 - Springer
Background Intrauterine adhesion (IUA) is a recurrent and refractory reproductive
dysfunction disorder for which menstrual blood-derived stromal cells (MenSCs) might be a …
dysfunction disorder for which menstrual blood-derived stromal cells (MenSCs) might be a …
Origin and composition of exosomes as crucial factors in designing drug delivery systems
J Rech, A Getinger-Panek, S Gałka, I Bednarek - Applied Sciences, 2022 - mdpi.com
Exosomes are a subpopulation of extravascular vesicles with a diameter of 30–150 nm.
They are cellular-communication mediators, often reaching very distant organism tissues …
They are cellular-communication mediators, often reaching very distant organism tissues …
Extracellular vesicles and exosomes: novel insights and perspectives on lung cancer from early detection to targeted treatment
Lung cancer demands innovative approaches for early detection and targeted treatment. In
addressing this urgent need, exosomes play a pivotal role in revolutionizing both the early …
addressing this urgent need, exosomes play a pivotal role in revolutionizing both the early …
miRNAs can affect intestinal epithelial barrier in inflammatory bowel disease
X Xiao, X Mao, D Chen, B Yu, J He, H Yan… - Frontiers in …, 2022 - frontiersin.org
The most obvious pathological characterization of inflammatory bowel disease (IBD) is
intestinal epithelium erosion and severe inflammation invasion. Micro-ribonucleic acids …
intestinal epithelium erosion and severe inflammation invasion. Micro-ribonucleic acids …
Role of regulatory non-coding RNAs in traumatic brain injury
Traumatic brain injury (TBI) is a potentially fatal health event that cannot be predicted in
advance. After TBI occurs, it can have enduring consequences within both familial and …
advance. After TBI occurs, it can have enduring consequences within both familial and …
[HTML][HTML] Unique therapeutic potentialities of exosomes based nanodrug carriers to target tumor microenvironment in cancer therapy
Cancer is a complex syndrome with a high mortality rate worldwide due to the lack of
effective treatments. The lack of effective coordination between tumor cells and immune …
effective treatments. The lack of effective coordination between tumor cells and immune …
Engineered anti-EGFRvIII targeted exosomes induce apoptosis in glioblastoma multiforme
Background The drug delivery for treatment of glioblastoma multiforme (GBM) has been
unsatisfactory mainly due to the drug resistance and low targeting efficiency. The selective …
unsatisfactory mainly due to the drug resistance and low targeting efficiency. The selective …