Clinical delivery of circular RNA: lessons learned from RNA drug development

TL Young, KC Wang, AJ Varley, B Li - Advanced drug delivery reviews, 2023 - Elsevier
Circular RNAs (circRNA) represent a distinct class of covalently closed-loop RNA molecules,
which play diverse roles in regulating biological processes and disease states. The …

Exosomes: A potential tool for immunotherapy of ovarian cancer

X Gong, H Chi, DF Strohmer, AT Teichmann… - Frontiers in …, 2023 - frontiersin.org
Ovarian cancer is a malignant tumor of the female reproductive system, with a very poor
prognosis and high mortality rates. Chemotherapy and radiotherapy are the most common …

Advances in mRNA therapeutics for cancer immunotherapy: from modification to delivery

G Han, D Noh, H Lee, S Lee, S Kim, HY Yoon… - Advanced Drug Delivery …, 2023 - Elsevier
RNA vaccines have demonstrated their ability to solve the issues posed by the COVID-19
pandemic. This success has led to the renaissance of research into mRNA and their …

P65 mediated UBR4 in exosomes derived from menstrual blood stromal cells to reduce endometrial fibrosis by regulating YAP Ubiquitination

J Qi, X Zhang, S Zhang, S Wu, Y Lu, S Li, P Li… - Journal of …, 2023 - Springer
Background Intrauterine adhesion (IUA) is a recurrent and refractory reproductive
dysfunction disorder for which menstrual blood-derived stromal cells (MenSCs) might be a …

Origin and composition of exosomes as crucial factors in designing drug delivery systems

J Rech, A Getinger-Panek, S Gałka, I Bednarek - Applied Sciences, 2022 - mdpi.com
Exosomes are a subpopulation of extravascular vesicles with a diameter of 30–150 nm.
They are cellular-communication mediators, often reaching very distant organism tissues …

Extracellular vesicles and exosomes: novel insights and perspectives on lung cancer from early detection to targeted treatment

S Rahimian, H Najafi, B Afzali, M Doroudian - Biomedicines, 2024 - mdpi.com
Lung cancer demands innovative approaches for early detection and targeted treatment. In
addressing this urgent need, exosomes play a pivotal role in revolutionizing both the early …

miRNAs can affect intestinal epithelial barrier in inflammatory bowel disease

X Xiao, X Mao, D Chen, B Yu, J He, H Yan… - Frontiers in …, 2022 - frontiersin.org
The most obvious pathological characterization of inflammatory bowel disease (IBD) is
intestinal epithelium erosion and severe inflammation invasion. Micro-ribonucleic acids …

Role of regulatory non-coding RNAs in traumatic brain injury

S Li, N Qiu, A Ni, MH Hamblin, KJ Yin - Neurochemistry international, 2023 - Elsevier
Traumatic brain injury (TBI) is a potentially fatal health event that cannot be predicted in
advance. After TBI occurs, it can have enduring consequences within both familial and …

[HTML][HTML] Unique therapeutic potentialities of exosomes based nanodrug carriers to target tumor microenvironment in cancer therapy

SU Khan, MU Khan, Y Gao, MI Khan, SM Puswal… - Opennano, 2022 - Elsevier
Cancer is a complex syndrome with a high mortality rate worldwide due to the lack of
effective treatments. The lack of effective coordination between tumor cells and immune …

Engineered anti-EGFRvIII targeted exosomes induce apoptosis in glioblastoma multiforme

R Rahmani, J Kiani, WY Tong, M Soleimani… - Journal of Drug …, 2023 - Taylor & Francis
Background The drug delivery for treatment of glioblastoma multiforme (GBM) has been
unsatisfactory mainly due to the drug resistance and low targeting efficiency. The selective …