Mechanisms mediating enhanced neutralization efficacy of staphylococcal enterotoxin B by combinations of monoclonal antibodies
Staphylococcal enterotoxin B (SEB) is a superantigen that cross-links the major
histocompatibility complex class II and specific V-β chains of the T-cell receptor, thus forming …
histocompatibility complex class II and specific V-β chains of the T-cell receptor, thus forming …
Isotype switching increases efficacy of antibody protection against staphylococcal enterotoxin B-induced lethal shock and Staphylococcus aureus sepsis in mice
AK Varshney, X Wang, JL Aguilar, MD Scharff, BC Fries - MBio, 2014 - Am Soc Microbiol
Staphylococcal enterotoxin B (SEB) is a potent toxin that is produced by Staphylococcus
aureus strains and is classified as a category B select agent. We have previously shown that …
aureus strains and is classified as a category B select agent. We have previously shown that …
3, 3′-Diindolylmethane ameliorates staphylococcal enterotoxin B–Induced acute lung injury through alterations in the expression of MicroRNA that target apoptosis …
3, 3′-Diindolylmethane (DIM), a natural indole found in cruciferous vegetables, has
significant anti-cancer and anti-inflammatory properties. In this current study, we investigated …
significant anti-cancer and anti-inflammatory properties. In this current study, we investigated …
Engineered pH-dependent recycling antibodies enhance elimination of Staphylococcal enterotoxin B superantigen in mice
ABSTRACT A new modality in antibody engineering has emerged in which the antigen
affinity is designed to be pH dependent (PHD). In particular, combining high affinity binding …
affinity is designed to be pH dependent (PHD). In particular, combining high affinity binding …
Structural insights into the binding of nanobodies to the Staphylococcal enterotoxin B
X Zong, P Liu, Z Wang, H Zhu, C Zhong… - International Journal of …, 2024 - Elsevier
Abstract Staphylococcal Enterotoxin Type B (SEB), produced by Staphylococcus aureus
bacteria, is notorious for inducing severe food poisoning and toxic shock syndrome. While …
bacteria, is notorious for inducing severe food poisoning and toxic shock syndrome. While …
A highly neutralizing human monoclonal antibody targeting a novel linear epitope on staphylococcal enterotoxin B
H Fan, L Zhao, W Wang, F Yu, H Jing… - Human Vaccines & …, 2024 - Taylor & Francis
ABSTRACT Staphylococcal Enterotoxin B (SEB), produced by Staphylococcus aureus (S.
aureus), is a powerful superantigen that induces severe immune disruption and toxic shock …
aureus), is a powerful superantigen that induces severe immune disruption and toxic shock …
Superantigen staphylococcal enterotoxin C1 inhibits the growth of bladder cancer
T Liu, L Li, L Yin, H Yu, H Jing, Y Liu… - Bioscience …, 2017 - academic.oup.com
Superantigens can induce cell-mediated cytotoxicity preferentially against MHC II-positive
target cells with large amounts of inflammatory cytokines releasing. In this study …
target cells with large amounts of inflammatory cytokines releasing. In this study …
MHC class II activation and interferon-γ mediate the inhibition of neutrophils and eosinophils by staphylococcal enterotoxin type A (SEA)
AP Ferreira-Duarte, AS Pinheiro-Torres… - Frontiers in cellular …, 2017 - frontiersin.org
Staphylococcal enterotoxins are classified as superantigens that act by linking T-cell
receptor with MHC class II molecules, which are expressed on classical antigen-presenting …
receptor with MHC class II molecules, which are expressed on classical antigen-presenting …
[PDF][PDF] 金黄色葡萄球菌肠毒素B 功能表位及中和抗体研究进展
胡乃静， 罗龙龙， 乔春霞… - 中国药理学与毒理学杂志, 2020 - cjpt.magtechjournal.com
金黄色葡萄球菌(金葡菌) 肠毒素B (SEB), 是造成食物中毒乃至中毒性休克综合征的主要病因.
SEB 也是一种超级抗原, 可以刺激T 细胞, 能够同时与抗原呈递细胞上的主要组织相容性复合物 …
SEB 也是一种超级抗原, 可以刺激T 细胞, 能够同时与抗原呈递细胞上的主要组织相容性复合物 …
[PDF][PDF] Staphylococcus aureuksen enterotoksiini isotyyppi A: ta kohdentavien vasta-ainefragmenttien kiteyttäminen
K Kulmakorpi - 2022 - erepo.uef.fi
Staphylococcus aureus on ruokamyrkytyksissä ja sairaalainfektioissa yleinen
opportunistinen patogeeni. S. aureus tuottaa useita mikrobimyrkkyjä, joista yksi ryhmä ovat …
opportunistinen patogeeni. S. aureus tuottaa useita mikrobimyrkkyjä, joista yksi ryhmä ovat …