This review considers the role of α-cells in β-cell generation and regeneration. We describe
recent evidence obtained from lineage-tracing studies showing that α-cells can serve as …

Diabetes occurs when the pancreas fails to pro-duce and secrete sufficient insulin for the
maintenance of glucose homeostasis. Although many factors required for β-cell …

BACKGROUND & AIMS: The tumor suppressor menin is recognized as a key regulator of
pancreatic islet development, proliferation, and β-cell function, whereas its role in α cells …

The existence of adult β-cell progenitors remains the most controversial developmental
biology topic in diabetes research. It has been reported that β-cell progenitors can be …

A possible association between glucagon-like peptide-1 (GLP-1) analogs and incidences of
pancreatitis has been suggested based on clinical studies. In male and female diabetic …

Glucagon action is transduced by a G protein-coupled receptor located in liver, kidney,
intestinal smooth muscle, brain, adipose tissue, heart, pancreatic β-cells, and placenta …

This study investigates the effects of intermittent overnight fasting in streptozotocin‐induced
diabetic rats (STZ rats). Over 30 days, groups of 5‐6 control or STZ rats were allowed free …

Insulin-producing pancreatic islet β cells (β-cells) are destroyed, severely depleted or
functionally impaired in diabetes. Therefore, replacing functional β-cell mass would advance …

The functional equivalence of P ax6/eyeless genes across distantly related animal phyla has
been one of central findings on which evo‐devo studies is based. In this study, we show that …

The pancreas is composed of two compartments that deliver digestive enzymes and
endocrine hormones to control the blood sugar level. The endocrine pancreas consists of …