The pervasive nature of drug-protein binding in pharmacology has attracted the attention of
investigators from many disciplines. Much of the pharmacology is, in the last analysis …

About 70 to 80% of an oral dose of digoxin is absorbed, mainly in the proximal part of the
small intestine. The degree of binding to serum albumin is 20 to 30%. Digoxin is extensively …

Several recent reports have shown that plasma concentrations of digoxin increase when
quinidine is administered along with digoxin; the present study was designed to explore the …

Pharmacokinetic data in obesity are only available for a limited number of drugs. The rate or
extent of drug absorption is not known to be altered by obesity which is not complicated by …

Radioimmunoassayed serum concentration and urinary excretion data for digoxin from
azotemic patients were characterized using a 2‐compartment open model. Urinary excretion …

The binding of drugs to proteins is an important pharmacokinetic parameter. Many methods
are available for the study of drug protein binding phenomena and there are also many …

Development of submodels of organs within physiologically-based pharmacokinetic (PBPK)
principles and beyond simple perfusion limitations may be challenging because of …

Five tables are presented that provide guidelines for drug usage in patients with renal
insufficiency. The data are derived from the current medical literature. If specific information …

The intestinal absorption of digoxin is essentially a passive non-saturable diffusion process,
although a saturable carrier-mediated component also plays an important role. The …

Haemodialysis is utilised therapeutically as supportive treatment for end-stage renal disease
(ESRD). In conjunction with haemodialysis therapy, ESRD patients frequently receive a …