Drugs and other xenobiotics may interact with macromolecules in various body fluids and
tissues. Binding of drugs to macromolecules influences both pharmacodynamics and …

Abstract 1 Three cases are described in which renal failure was accompanied by a lowered
apparent volume of distribution of digoxin. In two cases this resulted in frank digoxin toxicity …

A physiologically based pharmacokinetic model for digoxin disposition developed in the rat
was modified to account for the interspecies differences in tissue-to-plasma digoxin …

Animals undergo substantial changes in many physiologic and biochemical functions as a
natural consequence of aging. In the absence of disease or other pathologic conditions …

Study Objective. To determine digoxin pharmacokinetics in subjects with different degrees of
renal function using fluorescence polarization immunoassay (FPIA), which is associated with …

The clinical use of digoxin is complicated by a large number of drug interactions leading to
severe toxicity of the cardiac glycoside. The discovery that digoxin is actively secreted by the …

The purpose of this study was to determine if there is a linear relationship between oral
doses of digoxin and various measurements of steady-state digoxin plasma concentration …

Plasma protein binding of many drugs is impaired in patients with renal disease. This often
results in a larger apparent volume of distribution and a larger clearance of the drug …

Serum, right atrial myocardium and skeletal muscle collected from 32 adult patients
undergoing open heart surgery were analyzed for digoxin by radioimmunoassay …

To express growth-related changes in physiologic or other functions in forms usable for
kinetic modeling, we are interested in identifying regular relationships that take the form of …