Microglial cells are the major immune cells of the central nervous system (CNS), and directly
react to neurodegeneration, but other immune cell types are also able to react to pathology …

T cells play an important role in immunity and repair and are implicated in diseases,
including blood cancers, viral infections, and inflammation, making them attractive targets for …

Multiple sclerosis (MS) is the most frequent demyelinating disease and a leading cause for
disability in young adults. Despite significant advances in immunotherapies in recent years …

Multiple psychiatric disorders have been associated with abnormalities in both the innate
and adaptive immune systems. The role of these abnormalities in pathogenesis, and …

Systemic immunity supports lifelong brain function. Obesity posits a chronic burden on
systemic immunity. Independently, obesity was shown as a risk factor for Alzheimer's …

The interaction between peripheral immune cells and the brain is an important component of
the neuroimmune axis. Unconventional T cells, which include natural killer T (NKT) cells …

Neurodegenerative diseases are closely related to inflammatory and autoimmune events,
suggesting that the dysregulation of the immune system is a key pathological factor. Both …

Emerging evidence demonstrates that adaptive immunity influences the pathobiology of
neurodegenerative disorders. Misfolded aggregated self-proteins can break immune …

This article describes commonly used experimental and clinical biomarkers of neuronal
injury and neurodegeneration for the evaluation of neuropathology and monitoring of …

Through considerable effort in research and clinical studies, the immune system has been
identified as a participant in the onset and progression of brain injury after ischaemic stroke …